Baroreflex function in conscious rats submitted to iron overload.
dc.contributor.author | Cardoso, Leonardo Máximo | |
dc.contributor.author | Pedrosa, Maria Lúcia | |
dc.contributor.author | Silva, Marcelo Eustáquio | |
dc.contributor.author | Moraes, Márcio Flávio Dutra | |
dc.contributor.author | Colombari, Eduardo | |
dc.contributor.author | Chianca Júnior, Deoclécio Alves | |
dc.date.accessioned | 2012-11-26T13:29:38Z | |
dc.date.available | 2012-11-26T13:29:38Z | |
dc.date.issued | 2005 | |
dc.description.abstract | Our hypothesis is that iron accumulated in tissue, rather than in serum, may compromise cardiovascular control. Male Fischer 344 rats weighing 180 to 220 g were divided into 2 groups. In the serum iron overload group (SIO, N = 12), 20 mg elemental iron was injected ip daily for 7 days. In the tissue iron overload group (TIO, N = 19), a smaller amount of elemental iron was injected (10 mg, daily) for 5 days followed by a resting period of 7 days. Reflex heart rate responses were elicited by iv injections of either phenylephrine (0.5 to 5.0 µg/kg) or sodium nitroprusside (1.0 to 10.0 µg/kg). Baroreflex curves were determined and fitted to sigmoidal equations and the baroreflex gain coefficient was evaluated. To evaluate the role of other than a direct effect of iron on tissue, acute treatment with the iron chelator deferoxamine (20 mg/kg, iv) was performed on the TIO group and the baroreflex was re-evaluated. At the end of the experiments, evaluation of iron levels in serum confirmed a pronounced overload for the SIO group (30-fold), in contrast to the TIO group (2-fold). Tissue levels of iron, however, were higher in the TIO group. The SIO protocol did not produce significant alterations in the baroreflex curve response, while the TIO protocol produced a nearly 2-fold increase in baroreflex gain (-4.34 ± 0.74 and -7.93 ± 1.08 bpm/mmHg, respectively). The TIO protocol animals treated with deferoxamine returned to sham levels of baroreflex gain (-3.7 ± 0.3 sham vs -3.6 ± 0.2 bpm/mmHg) 30 min after the injection. Our results indicate an effect of tissue iron overload on the enhancement of baroreflex sensitivity. | pt_BR |
dc.identifier.citation | CARDOSO, L. M. et al. Baroreflex function in conscious rats submitted to iron overload. Brazilian Journal of Medical and Biological Research, v. 38, n. 2, p. 205-214, fev. 2005. Disponível em: <http://www.scielo.br/pdf/bjmbr/v38n2/5462.pdf>. Acesso em: 26 nov. 2012. | pt_BR |
dc.identifier.issn | 1414431X | |
dc.identifier.uri | http://www.repositorio.ufop.br/handle/123456789/1813 | |
dc.language.iso | en_US | pt_BR |
dc.rights.license | Todo o conteúdo do periódico Brazilian Journal of Medical and Biological Research, exceto onde identificado, está licenciado sob uma licença Creative Commons 4.0 que permite copiar, distribuir e transmitir o trabalho em qualquer suporte ou formato desde que sejam citados o autor e o licenciante. Fonte: Brazilian Journal of Medical and Biological Research <http://www.scielo.br/scielo.php?script=sci_serial&pid=0100-879X&lng=en&nrm=iso>. Acesso em: 20 out. 2016. | |
dc.subject | Blood pressure | pt_BR |
dc.subject | Deferoxamine | pt_BR |
dc.subject | Iron dextran | pt_BR |
dc.subject | Baroreflex | pt_BR |
dc.subject | Iron overload | pt_BR |
dc.subject | Heart rate | pt_BR |
dc.title | Baroreflex function in conscious rats submitted to iron overload. | pt_BR |
dc.type | Artigo publicado em periodico | pt_BR |
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