Nanotechnology applied to the treatment of malaria.

dc.contributor.authorMagalhães, Nereide Stela Santos
dc.contributor.authorMosqueira, Vanessa Carla Furtado
dc.date.accessioned2014-11-14T19:13:58Z
dc.date.available2014-11-14T19:13:58Z
dc.date.issued2010
dc.description.abstractDespite the fact that we live in an era of advanced technology and innovation, infectious diseases, like malaria, continue to be one of the greatest health challenges worldwide. The main drawbacks of conventional malaria chemotherapy are the development of multiple drug resistance and the non-specific targeting to intracellular parasites, resulting in high dose requirements and subsequent intolerable toxicity. Nanosized carriers have been receiving special attention with the aim of minimizing the side effects of drug therapy, such as poor bioavailability and the selectivity of drugs. Several nanosized delivery systems have already proved their effectiveness in animal models for the treatment and prophylaxis of malaria. A number of strategies to deliver antimalarials using nanocarriers and the mechanisms that facilitate their targeting to Plasmodium spp.-infected cells are discussed in this review. Taking into account the peculiarities of malaria parasites, the focus is placed particularly on lipid-based (e.g., liposomes, solid lipid nanoparticles and nano and microemulsions) and polymer-based nanocarriers (nanocapsules and nanospheres). This review emphasizes the main requirements for developing new nanotechnology-based carriers as a promising choice in malaria treatment, especially in the case of severe cerebral malaria.pt_BR
dc.identifier.citationMAGALHÃES, N. S. S; MOSQUEIRA V. C. F. Nanotechnology applied to the treatment of malaria. Advanced Drug Delivery Reviews, v. 62, p. 560-575, 2010. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0169409X09003652>. Acesso em: 20 ago. 2014.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.addr.2009.11.024
dc.identifier.issn0169-409X
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/3866
dc.language.isoen_USpt_BR
dc.rights.licenseO periódico Advanced Drug Delivery Reviews concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença:3460320566734.pt_BR
dc.subjectMalariapt_BR
dc.subjectNanocarrierspt_BR
dc.subjectLiposomespt_BR
dc.subjectNanocapsulespt_BR
dc.subjectAntimalarialspt_BR
dc.titleNanotechnology applied to the treatment of malaria.pt_BR
dc.typeArtigo publicado em periodicopt_BR

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