Controlled release and cell viability of ketoconazole incorporated in PEG 4000 derivatives.
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Data
2023
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Resumo
In recent years, polymeric materials have been gaining prominence in studies of controlled
release systems to obtain improvements in drug administration. These systems present several
advantages compared with conventional release systems, such as constant maintenance in the blood
concentration of a given drug, greater bioavailability, reduction of adverse effects, and fewer dosages
required, thus providing a higher patient compliance to treatment. Given the above, the present work
aimed to synthesize polymeric matrices derived from polyethylene glycol (PEG) capable of promoting
the controlled release of the drug ketoconazole in order to minimize its adverse effects. PEG 4000 is
a widely used polymer due to its excellent properties such as hydrophilicity, biocompatibility, and
non-toxic effects. In this work, PEG 4000 and derivatives were incorporated with ketoconazole. The
morphology of polymeric films was observed by AFM and showed changes on the film organization
after drug incorporation. In SEM, it was possible to notice spheres that formed in some incorporated
polymers. The zeta potential of PEG 4000 and its derivatives was determined and suggested that
the microparticle surfaces showed a low electrostatic charge. Regarding the controlled release, all
the incorporated polymers obtained a controlled release profile at pH 7.3. The release kinetics of
ketoconazole in the samples of PEG 4000 and its derivatives followed first order for PEG 4000 HYDR
INCORP and Higuchi for the other samples. Cytotoxicity was determined and PEG 4000 and its
derivatives were not cytotoxic.
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Ketoconazole, Polymers, Controlled release, Zeta potential, Cell viability
Citação
INÁCIO, C. R. et al. Controlled release and cell viability of ketoconazole incorporated in PEG 4000 derivatives. Polymers, v. 15, n. 11, artigo 2513, 2023. Disponível em: <https://www.mdpi.com/2073-4360/15/11/2513>. Acesso em: 01 ago. 2023.