Microexon gene transcriptional profiles and evolution provide insights into blood processing by the Schistosoma japonicum esophagus.
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2018
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Adult schistosomes have a well-developed alimentary tract comprising an oral sucker
around the mouth, a short esophagus and a blind ending gut. The esophagus is not simply a
muscular tube for conducting blood from the mouth to gut but is divided into compartments,
surrounded by anterior and posterior glands, where processing of ingested blood is initiated.
Self-cure of rhesus macaques from a Schistosoma japonicum infection appears to operate
by blocking the secretory functions of these glands so that the worms cease feeding and
slowly starve to death. Here we use subtractive RNASeq to characterise the genes encoding
the principal secretory products of S. japonicum esophageal glands, preparatory to evaluating
their relevance as targets of the self-cure process.
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LI, X. H. et al. Microexon gene transcriptional profiles and evolution provide insights into blood processing by the Schistosoma japonicum esophagus. PLoS Neglected Tropical Diseases, v. 12, p. 1-22, 2018. Disponível em: <http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0006235>. Acesso em: 05 abr. 2018.