Kinetics of cell migration to the dermis and hypodermis in dogs vaccinated with antigenic compounds of Leishmania braziliensis plus saponin.

dc.contributor.authorSouza, Juliana Vitoriano de
dc.contributor.authorReis, Alexandre Barbosa
dc.contributor.authorMoreira, Nádia das Dores
dc.contributor.authorGiunchetti, Rodolfo Cordeiro
dc.contributor.authorOliveira, Rodrigo Corrêa de
dc.contributor.authorCarneiro, Cláudia Martins
dc.date.accessioned2015-01-22T14:53:43Z
dc.date.available2015-01-22T14:53:43Z
dc.date.issued2008
dc.description.abstractThe search for new immunobiologicals against canine visceral leishmaniasis (CVL) has intensified in the last decade. However, it still remains to be elucidated that mechanisms of the innate immune response in situ after immunization (a.i.). The aim of this study was to investigate the kinetics of cell migration in the skin dogs with distinct antigenic compounds of the LBSap vaccine. Our major findings indicated that saponin adjuvant alone or combined with Leishmania braziliensis antigen induced strong local acute inflammatory reaction. However, these reactions not progressed to ulcerated lesions. Overall, the cell profile found in Sap and LBSap was composed of neutrophils, lymphocytes and eosinophils. There was also increased production of iNOS in Sap and LBSap groups. Thus, we can conclude that dogs immunized by LBSap and the saponin adjuvant elicited a potential innate-immune activations status compatible with effective control of the resistance to infection by Leishmania and contributing to a better understanding of the innate-immunity events induced by the LBSap vaccine.pt_BR
dc.identifier.citationSOUZA, J. V. et al. Kinetics of cell migration to the dermis and hypodermis in dogs vaccinated with antigenic compounds of Leishmania braziliensis plus saponin. Vaccine, Guildford, v. 26, p. 3922-3931, 2008. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0264410X08005537>. Acesso em: 15 ago. 2014.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.vaccine.2008.04.084
dc.identifier.issn0264-410X
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/4328
dc.language.isoen_USpt_BR
dc.rights.licenseO periódico Vaccine concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3446031456908.pt_BR
dc.subjectInflammation and cell migrationpt_BR
dc.subjectCanine visceral leishmaniasispt_BR
dc.subjectInnate-immune responsept_BR
dc.subjectVaccinept_BR
dc.subjectSaponinpt_BR
dc.titleKinetics of cell migration to the dermis and hypodermis in dogs vaccinated with antigenic compounds of Leishmania braziliensis plus saponin.pt_BR
dc.typeArtigo publicado em periodicopt_BR

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