Expression and characterization of LTx2, a neurotoxin from Lasiodora sp. effecting on calcium channels.

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dc.contributor.authorDutra, Alexandre Augusto de Assis
dc.contributor.authorSousa, Lucas Oliveira
dc.contributor.authorResende, Rodrigo Ribeiro
dc.contributor.authorBrandão, Rogélio Lopes
dc.contributor.authorKalapothakis, Evanguedes
dc.contributor.authorCastro, Ieso de Miranda
dc.date.accessioned2012-07-18T18:10:30Z
dc.date.available2012-07-18T18:10:30Z
dc.date.issued2008
dc.description.abstractHere, we described the expression and characterization of the recombinant toxin LTx2, which was previously isolated from the venomous cDNA library of a Brazilian spider, Lasiodora sp. (Mygalomorphae, Theraphosidae). The recombinant toxin found in the soluble and insoluble fractions was purified by reverse phase high-performance liquid chromatography (HPLC). Ca2+ imaging analysis revealed that the recombinant LTx2 acts on calcium channels of BC3H1 cells, blocking L-type calcium channels.pt_BR
dc.identifier.citationDUTRA, A. A. A. et al. Expression and characterization of LTx2, a neurotoxin from Lasiodora sp. effecting on calcium channels. Peptides, v. 29, n. 9, p. 1505-1513, set. 2008. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0196978108002131. Acesso em: 18 jul. 2012.pt_BR
dc.identifier.issn01969781
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/1165
dc.language.isoen_USpt_BR
dc.rights.licenseO periódico Peptides concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3266011353103.
dc.subjectCalcium channelpt_BR
dc.subjectVenompt_BR
dc.subjectSpider toxinspt_BR
dc.subjectLasiodorapt_BR
dc.subjectcDNApt_BR
dc.subjectExpressionpt_BR
dc.titleExpression and characterization of LTx2, a neurotoxin from Lasiodora sp. effecting on calcium channels.pt_BR
dc.typeArtigo publicado em periodicopt_BR

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