Coinfection with Zika Virus (ZIKV) and dengue virus results in preferential ZIKV transmission by vector bite to vertebrate host.
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2018
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Background. Several tropical cities are permissive to Aedes aegypti and dengue virus (DENV) endemicity and have allowed for
invasion and circulation of Zika virus (ZIKV) in the same areas. People living in arbovirus-endemic regions have been simultaneously infected with ≥2 arboviruses.
Methods. A. aegypti mosquitoes from Manaus, the capital city of Amazonas State in Brazil, were coinfected with circulating
strains of DENV and ZIKV. The coinfected vectors were allowed to bite BALB/c mice.
Results. A. aegypti from Manaus is highly permissive to monoinfection and coinfection with DENV and ZIKV and is capable
of cotransmitting both pathogens by bite. Coinfection strongly influences vector competence, favoring transmission of ZIKV to the
vertebrate host.
Conclusions. This finding suggests that A. aegypti is an efficient vector of ZIKV and that ZIKV would be preferentially transmitted by coinfected A. aegypti. Coinfection in the vector population should be considered a new critical epidemiological factor and
may represent a major public health challenge.
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Aedes aegypti
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CHAVES, B. A. et al. Coinfection with Zika Virus (ZIKV) and dengue virus results in preferential ZIKV transmission by vector bite to vertebrate host. The Journal of Infectious Diseases, v. 218, n. 4, p. 563–571, ago. 2018. Disponível em: <https://academic.oup.com/jid/article/218/4/563/4962451>. Acesso em: 22 fev. 2019.