PLA-b-SMA as an amphiphilic diblock copolymer for encapsulation of lipophilic cargo.

dc.contributor.authorBall, Lauren Elizabeth
dc.contributor.authorPfukwa, Rueben
dc.contributor.authorSiqueira, Raoni Pais
dc.contributor.authorMosqueira, Vanessa Carla Furtado
dc.contributor.authorKlumperman, Bert
dc.date.accessioned2023-10-18T18:55:08Z
dc.date.available2023-10-18T18:55:08Z
dc.date.issued2023pt_BR
dc.description.abstractThe encapsulation of active pharmaceutical ingredients (APIs) within drug delivery systems such as polymeric nanoparticles (PNPs) vastly improves the therapeutic efficiency of the incorporated APIs. PNPs synthesized using amphiphilic block copolymers are efficient drug delivery systems as the hydrophobic block facilitates the encapsulation of lipophilic components and the hydrophilic block constitutes the hairy corona of the PNP that stabilizes the nanocarriers against aggregation in solution. Poly(styrene-alt-maleic acid) (SMA) is an attractive polymer for the hydrophilic corona of PLA-based nanoparticles as it allows for post polymerization functionalization and aids in the prevention of NP aggregation. The synthesis of a novel PLA-b-SMA block copolymer, via sequential ring opening polymerization (ROP) and reversible addition–fragmentation chain transfer (RAFT) polymerization, is presented. PLA macro-CTAs, synthesized via ROP, can be chain extended via RAFT copolymerization of styrene and maleic anhydride to yield PLA-b-SMAnh and via RAFT polymerization of N-vinylpyrrolidone to yield PLA-b-PVP block copolymers. Controlled hydrolysis of the anhydride moieties converts PLA-b-SMAnh into PLA-b-SMA. Monodisperse PLA-b-SMA and PLA-b-PVP nanoparticles (NPs) ranging in diameter between 60 and 220 nm are prepared. The lipophilic fluorescent dye DiI is encapsulated within the NPs successfully and these fluorescent NPs are used in a preliminary cell uptake study.pt_BR
dc.identifier.citationBALL, L. E. et al. PLA-b-SMA as an amphiphilic diblock copolymer for encapsulation of lipophilic cargo. Macromolecular Chemistry and Physics, v. 224, n. 1, artigo 2200212, jan. 2023. Disponível em: <https://onlinelibrary.wiley.com/doi/epdf/10.1002/macp.202200212>. Acesso em: 01 ago. 2023.pt_BR
dc.identifier.doihttps://doi.org/10.1002/macp.202200212pt_BR
dc.identifier.issn1521-3935
dc.identifier.urihttp://www.repositorio.ufop.br/jspui/handle/123456789/17604
dc.language.isoen_USpt_BR
dc.rightsabertopt_BR
dc.rights.licenseThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. Fonte: PDF do artigo.pt_BR
dc.titlePLA-b-SMA as an amphiphilic diblock copolymer for encapsulation of lipophilic cargo.pt_BR
dc.typeArtigo publicado em periodicopt_BR

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