Association among ACE, ESR1 polymorphisms and preeclampsia in Brazilian pregnant women.
dc.contributor.author | Lopes, Ana Cristina dos Santos | |
dc.contributor.author | Perucci, Luiza Oliveira | |
dc.contributor.author | Evangelista, Fernanda Cristina Gontijo | |
dc.contributor.author | Godoi, Lara Carvalho | |
dc.contributor.author | Sabino, Adriano de Paula | |
dc.contributor.author | Gomes, Karina Braga | |
dc.contributor.author | Silva, André Talvani Pedrosa da | |
dc.contributor.author | Dusse, Luci Maria Sant'Ana | |
dc.contributor.author | Alpoim, Patrícia Nessralla | |
dc.date.accessioned | 2020-03-10T11:01:50Z | |
dc.date.available | 2020-03-10T11:01:50Z | |
dc.date.issued | 2019 | |
dc.description.abstract | Background: Genetic, immune and environmental factors are involved in preeclampsia (PE) etiopathogenesis. Considering that hypertension and poor placental perfusion are important features in PE, polymorphisms in the angiotensin-converting enzyme (ACE) and estrogen nuclear receptor 1 (ESR1) genes could be involved in the predisposition and/or development of the disease. The aim of this study was to evaluate if polymorphisms in ACE and ESR1 genes were associated with PE occurrence. Material and Methods: This case-control study included 209 Brazilian pregnant women (107 with severe PE and 102 normotensive controls). The polymorphisms were investigated by polymerase chain reaction (PCR) followed by polyacrylamide gel electrophoresis. Results: No significant difference between PE versus normotensive pregnant women, as well as early versus late PE, was observed when compared the allelic and genotypic frequencies of insertion/deletion polymorphism in intron 16 of the ACE gene and the single nucleotide polymorphisms (SNPs - rs2234693 and rs9340799) of the ESR1 gene. Conclusion: This pioneer study involving Brazilian women showed no association among the studied polymorphisms and PE, which suggests that ins/del ACE and SNPs ESR1 do not contribute to this disease occurrence in Brazil. | pt_BR |
dc.identifier.citation | LOPES, A. C. S. et al. Association among ACE, ESR1 polymorphisms and preeclampsia in Brazilian pregnant women. Molecular and cellular probes, v. 45, p. 43-47, jun. 2019. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0890850819300350?via%3Dihub>. Acesso em: 10 fev. 2020. | pt_BR |
dc.identifier.doi | https://doi.org/10.1016/j.mcp.2019.04.004 | pt_BR |
dc.identifier.issn | 0890-8508 | |
dc.identifier.uri | http://www.repositorio.ufop.br/handle/123456789/11972 | |
dc.identifier.uri2 | https://www.sciencedirect.com/science/article/pii/S0890850819300350?via%3Dihub | pt_BR |
dc.language.iso | en_US | pt_BR |
dc.rights | restrito | pt_BR |
dc.subject | Preeclampsia | pt_BR |
dc.subject | Hypertension | pt_BR |
dc.title | Association among ACE, ESR1 polymorphisms and preeclampsia in Brazilian pregnant women. | pt_BR |
dc.type | Artigo publicado em periodico | pt_BR |
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