Morphometric evaluation and nonclassical criteria for the diagnosis of HPV infection and cytological atypia in cervical samples.
dc.contributor.author | Sana, Dandara Emery Morais | |
dc.contributor.author | Miranda, Priscila Mayrink de | |
dc.contributor.author | Pitol, Bruna Caroline Vieira | |
dc.contributor.author | Silva, Nayara Nascimento Toledo | |
dc.contributor.author | Silva, Ismael Dale Cotrim Guerreiro da | |
dc.contributor.author | Stocco, Rita de Cássia | |
dc.contributor.author | Beçak, Willy | |
dc.contributor.author | Lima, Angélica Alves | |
dc.contributor.author | Carneiro, Cláudia Martins | |
dc.date.accessioned | 2017-02-23T17:14:27Z | |
dc.date.available | 2017-02-23T17:14:27Z | |
dc.date.issued | 2013 | |
dc.description.abstract | Herein, we evaluated cervical samples from normal tissue or HPV-infected tissue, to determine if the relative nuclear/cytoplasmic ratio (NA/CA) and the presence of nonclassical cytological criteria are a novel cytological criterion for the diagnosis of HPV. Significantly, larger NA/CA ratios were found for the HPV−ATYPIA+ and HPV+ATYPIA+ groups compared with HPV−ATYPIA− group, regardless of collection method. For the samples collected with a spatula, only three samples from the HPV−ATIPIA− group showed four or more nonclassical parameters (i.e., were positive), while a larger number of the samples in the HPV−ATYPIA+, HPV+ATYPIA−, and HPV+ATYPIA+ groups were positive (13, 4, and 13 samples, respectively). Among those collected with a brush, no sample showed four or more nonclassical criteria in the HPV−ATYPIA− group, while a number of samples were positive in the HPV−ATYPIA+, HPV+ATYPIA−, and HPV+ATYPIA+ groups (4, 3, and 4 samples, respectively). HPV infection was associated with significant morphometrical changes; no increase in the NA/CA ratio was found in the HPV+ATYPIA- samples, compared with the HPV−ATIPIA− samples collected with either a spatula or a brush. In conclusion, by including nonclassical cytological criteria into the patient diagnosis, we were able to reduce the number of false negative and false positive HPV diagnoses made using conventional cytology alone. Diagn. Cytopathol. | pt_BR |
dc.identifier.citation | SANA, D. E. M. et al. Morphometric evaluation and nonclassical criteria for the diagnosis of HPV infection and cytological atypia in cervical samples. Diagnostic Cytopathology, v. 41, n. 9, p.785-792, 2013. Disponível em: <http://onlinelibrary.wiley.com/doi/10.1002/dc.22955/abstract;jsessionid=F9558148044C5AD060CD7291C46D88E8.f04t04>. Acesso em: 10 jan. 2017. | pt_BR |
dc.identifier.doi | https://doi.org/10.1002/dc.22955 | |
dc.identifier.issn | 1097-0339 | |
dc.identifier.uri | http://www.repositorio.ufop.br/handle/123456789/7307 | |
dc.identifier.uri2 | http://onlinelibrary.wiley.com/doi/10.1002/dc.22955/abstract;jsessionid=F9558148044C5AD060CD7291C46D88E8.f04t04 | pt_BR |
dc.language.iso | en_US | pt_BR |
dc.rights | restrito | pt_BR |
dc.subject | Cervix-vaginal cytology | pt_BR |
dc.subject | Morphometry | pt_BR |
dc.subject | Molecular biology | pt_BR |
dc.title | Morphometric evaluation and nonclassical criteria for the diagnosis of HPV infection and cytological atypia in cervical samples. | pt_BR |
dc.type | Artigo publicado em periodico | pt_BR |