Psychotria viridis : chemical constituents from leaves and biological properties.
dc.contributor.author | Soares, Débora Barbosa da Silva | |
dc.contributor.author | Duarte, Lucienir Pains | |
dc.contributor.author | Cavalcanti, André Dias | |
dc.contributor.author | Silva, Fernando César | |
dc.contributor.author | Braga, Ariadne Duarte | |
dc.contributor.author | Lopes, Miriam Teresa Paz | |
dc.contributor.author | Takahashi, Jacqueline Aparecida | |
dc.contributor.author | Vieira Filho, Sidney Augusto | |
dc.date.accessioned | 2017-08-31T15:54:16Z | |
dc.date.available | 2017-08-31T15:54:16Z | |
dc.date.issued | 2017 | |
dc.description.abstract | The phytochemical study of hexane, chloroform and methanol extracts from leaves of Psychotria viridis resulted in the identification of: the pentacyclic triterpenes, ursolic and oleanolic acid; the steroids, 24-methylene-cycloartanol, stigmasterol and β-sitosterol; the glycosylated steroids 3-O-β-D-glucosyl-β- sitosterol and 3-O-β-D-glucosyl-stigmasterol; a polyunsaturated triterpene, squalene; the esters of glycerol, 1-palmitoylglycerol and triacylglycerol; a mixture of long chain hydrocarbons; the aldehyde nonacosanal; the long chain fat acids hentriacontanoic, hexadecanoic and heptadenoic acid; the ester methyl heptadecanoate; the 4-methyl-epi-quinate and two indole alkaloids, N,N-dimethyltryptamine (DMT) and N-methyltryptamine. The chemical structures were determined by means of spectroscopic (IR, 1H and 13C NMR, HSQC, HMBC and NOESY) and spectrometric (CG-MS and LCMS-ESI-ITTOF) methods. The study of biologic properties of P. viridis consisted in the evaluation of the acetylcholinesterase inhibition and cytotoxic activities. The hexane, chloroform, ethyl acetate and methanol extracts, the substances 24-methylene-cycloartanol, DMT and a mixture of 3-O-β-D-glucosyl-β-sitosterol and 3-O-β-D-glucosyl-stigmasterol showed cholinesterase inhibiting activity. This activity induced by chloroform and ethyl acetate extracts was higher than 90%. The methanol and ethyl acetate extracts inhibit the growth and/or induce the death of the tumor cells strains B16F10 and 4T1, without damaging the integrity of the normal cells BHK and CHO. DMT also demonstrated a marked activity against tumor cell strains B16F10 and 4T1. | pt_BR |
dc.identifier.citation | SOARES, D. B. S. et al. Psychotria viridis: chemical constituents from leaves and biological properties. Anais da Academia Brasileira de Ciências, v. 89, p. 927-938, 2017. Disponível em: <http://www.scielo.br/scielo.php?pid=S0001-37652017000300927&script=sci_arttext>. Acesso em: 29 ago. 2017. | pt_BR |
dc.identifier.issn | 1678-2690 | |
dc.identifier.uri | http://www.repositorio.ufop.br/handle/123456789/8637 | |
dc.language.iso | en_US | pt_BR |
dc.rights | aberto | pt_BR |
dc.rights.license | Os trabalhos publicados no periódico Anais da Academia Brasileira de Ciências, exceto onde identificado, está sob uma licença Creative Commons que permite copiar, distribuir e transmitir o trabalho desde que sejam citados o autor e o licenciante. Fonte: Anais da Academia Brasileira de Ciências <http://www.scielo.br/scielo.php?script=sci_serial&pid=0001-3765&lng=en&nrm=iso>. Acesso em: 23 jan. 2020. | pt_BR |
dc.subject | Rubiaceae | pt_BR |
dc.title | Psychotria viridis : chemical constituents from leaves and biological properties. | pt_BR |
dc.type | Artigo publicado em periodico | pt_BR |
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