New ruthenium complexes containing salicylic acid and derivatives induce triple-negative tumor cell death via the intrinsic apoptotic pathway.
dc.contributor.author | Graminha, Angelica Ellen | |
dc.contributor.author | Popolin, Cecília | |
dc.contributor.author | Araujo Neto, João Honorato de | |
dc.contributor.author | Correa, Rodrigo de Souza | |
dc.contributor.author | Oliveira, Katia Mara de | |
dc.contributor.author | Godoy, Luani Rezende | |
dc.contributor.author | Colina Vegas, Legna Andreina | |
dc.contributor.author | Ellena, Javier Alcides | |
dc.contributor.author | Batista, Alzir Azevedo | |
dc.contributor.author | Cominetti, Márcia Regina | |
dc.date.accessioned | 2023-11-24T18:53:32Z | |
dc.date.available | 2023-11-24T18:53:32Z | |
dc.date.issued | 2022 | pt_BR |
dc.description.abstract | In this work we present the synthesis and characterization of six new ruthenium compounds with general formulae [Ru(L)(dppb)(bipy)]PF6 and [Ru(L)(dppe)2]PF6 where L = salicylic acid (Sal), 4-aminosalicylic acid (AmSal) or 2,4-dihydroxybenzoic acid (DiSal), dppb = 1,4-bis(diphenylphosphino)butane, dppe = 1,2-bis (diphenylphosphino)ethane and bipy = 2,2′ -bipyridine. The complexes were characterized by elemental analysis, molar conductivity, cyclic voltammetry, NMR, UV–vis and IR spectroscopies, and two by X-ray crystallography. The 31P{1 H} NMR spectra of the complexes with the general formula [Ru(L)(dppe)2]PF6 showed that the phosphorus signals are solvent-dependent. Aprotic solvents, which form strong hydrogen bonds with the complexes, inhibit the free rotation of the salicylic acid-based, modifying the diphosphine cone angles, leading to distortion of the phosphorus signals in the NMR spectra. The cytotoxicity of the complexes was evaluated in MCF7, MDA-MB-231, SKBR3 human breast tumor cells, and MCF-10 non-tumor cell lines. The complexes with the structural formula [Ru(L)(dppe)2]PF6 were the most cytotoxic, and the complex [Ru(AmSal)(dppe)2]PF6 with L = 4-aminosalicylic acid ligand was the most selective for the MDA-MB-231 cell line. This complex interacts with the transferrin and induces apoptosis through the intrinsic pathway, as demonstrated by increased levels of proteins involved in apoptotic cell death. | pt_BR |
dc.identifier.citation | GRAMINHA, A. E. et al. New ruthenium complexes containing salicylic acid and derivatives induce triple-negative tumor cell death via the intrinsic apoptotic pathway. European Journal of Medicinal Chemistry, v. 243, artigo 114772, 2022. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0223523422006742>. Acesso em: 01 ago. 2023. | pt_BR |
dc.identifier.doi | https://doi.org/10.1016/j.ejmech.2022.114772 | pt_BR |
dc.identifier.issn | 0223-5234 | |
dc.identifier.uri | http://www.repositorio.ufop.br/jspui/handle/123456789/17870 | |
dc.identifier.uri2 | https://www.sciencedirect.com/science/article/pii/S0223523422006742 | pt_BR |
dc.language.iso | en_US | pt_BR |
dc.rights | restrito | pt_BR |
dc.subject | Ruthenium complexes | pt_BR |
dc.subject | Salicylic acids | pt_BR |
dc.subject | Cytotoxicity | pt_BR |
dc.subject | Cell death | pt_BR |
dc.title | New ruthenium complexes containing salicylic acid and derivatives induce triple-negative tumor cell death via the intrinsic apoptotic pathway. | pt_BR |
dc.type | Artigo publicado em periodico | pt_BR |
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