The oxidative response of mouse hearts is modulated by genetic background.
Nenhuma Miniatura Disponível
Data
2013
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
Background: Smoking plays an important role in cardiovascular diseases. However, the reasons why some individuals develop
those diseases and others do not remain to be explained.
Objective: This study aimed at assessing the redox profile of the heart of different mouse strains after exposure to
cigarette smoke.
Methods: Male mice of the Swiss (n = 10), C3H (n = 10), BALB/c (n = 10) and C57BL/6 (n = 10) strains were exposed to
cigarette smoke (12 cigarettes/day), while their respective controls (n = 10) were exposed to ambient air for 60 days. After
being euthanized, their heart was removed for biochemical analyses.
Results: Although the malondialdehyde content did not increase in any of the groups, catalase activity decreased in the Swiss
(p < 0.05) and BALB/c (p < 0.05) strain mice as compared with their respective control groups, while myeloperoxidase decreased
in the C3H (p < 0.05) and C57BL/6 (p < 0.001) strain mice as compared with their respective control groups. The reduced
glutathione content decreased in the Swiss, C3H, C57BL/6 (p < 0.05) and BALB/c (p < 0,001) strain mice as compared with their
respective control groups. Regarding reduced glutathione content, an increase was observed in the Swiss strain mice (p < 0.05),
while a decrease was observed in the C3H (p < 0.05) and BALB/c (p < 0.001) strain mice as compared with their respective
control groups. The reduced glutathione/reduced glutathione ratio showed a reduction in the Swiss and C57BL/6 (p < 0.05)
strain mice as compared with their respective control groups.
Conclusion: The genetic background of mice can influence the antioxidant response after exposure to cigarette smoke and
seems to be a determinant factor for redox imbalance in Swiss and C57BL/6 strain mice. Understanding antioxidant responses
and genetic background of C3H and BALB/c strain mice might provide important information regarding cardiac resistance to
cigarette smoke.
Descrição
Palavras-chave
Oxidative stress, Tobacco, Smoke, Genetic enhancement, Mice
Citação
SILVA, M. A. dos S. et al. The oxidative response of mouse hearts is modulated by genetic background. Arquivos Brasileiros de Cardiologia, v. 100, p. 157-163, 2013. Disponível em: <http://www.scielo.br/pdf/abc/v100n2/en_v100n2a08.pdf>. Acesso em: 21 out. 2015.