Computational identification and evolutionary relationships of the MicroRNA gene cluster miR-71/2 in protostomes.
dc.contributor.author | Gomes, Matheus de Souza | |
dc.contributor.author | Donoghue, Mark T. A. | |
dc.contributor.author | Muniyappa, Mohan Kumar | |
dc.contributor.author | Pereira, Roberta Verciano | |
dc.contributor.author | Cota, Renata Guerra de Sá | |
dc.contributor.author | Spillane, Charles | |
dc.date.accessioned | 2017-06-22T18:15:54Z | |
dc.date.available | 2017-06-22T18:15:54Z | |
dc.date.issued | 2013 | |
dc.description.abstract | MicroRNAs (miRNAs) are small noncoding RNA molecules which are processed into *20–24 nt molecules that can regulate the gene expression posttranscriptionally. MiRNA gene clusters have been identified in a range of species, where in miRNAs are often processed from polycistronic transcripts. In this study, a computational approach is used to investigate the extent of evolutionary conservation of the miR-71/2 cluster in animals, and to identify novel miRNAs in the miRNA cluster miR-71/2. The miR-71/2 cluster, consisting of copies of the miR-71 and miR-2 (including miR-13) families, was found to be Protostome-specific. Although, this cluster is highly conserved across the Protostomia, the miR-2 family is completely absent from the Deuterostomia species, while miR-71 is absent from the Vertebrata and Urochordata. The evolutionary conservation and clustering propensity of the miR-71/2 family across the Protostomes could indicate the common functional roles across the member species of the Protostomia. | pt_BR |
dc.identifier.citation | GOMES, M. de S. et al. Computational identification and evolutionary relationships of the MicroRNA gene cluster miR-71/2 in protostomes. Journal of Molecular Evolution, v. 76, p. 353-358, 2013. Disponível em: <https://link.springer.com/article/10.1007%2Fs00239-013-9563-2>. Acesso em: 23 fev. 2017. | pt_BR |
dc.identifier.doi | https://doi.org/10.1007/s00239-013-9563-2 | |
dc.identifier.issn | 1432-1432 | |
dc.identifier.uri | http://www.repositorio.ufop.br/handle/123456789/8049 | |
dc.identifier.uri2 | https://link.springer.com/article/10.1007%2Fs00239-013-9563-2 | pt_BR |
dc.language.iso | en_US | pt_BR |
dc.rights | restrito | pt_BR |
dc.title | Computational identification and evolutionary relationships of the MicroRNA gene cluster miR-71/2 in protostomes. | pt_BR |
dc.type | Artigo publicado em periodico | pt_BR |