Parasitological and immunological evaluation of a novel chemotherapeutic agent against visceral leishmaniasis.
dc.contributor.author | Pereira, Isabela Amorim Gonçalves | |
dc.contributor.author | Mendonça, Débora Vasconcelos Costa | |
dc.contributor.author | Tavares, Grasiele de Sousa Vieira | |
dc.contributor.author | Lage, Daniela Pagliara | |
dc.contributor.author | Ramos, Fernanda Fonseca | |
dc.contributor.author | Silva, João Augusto Oliveira da | |
dc.contributor.author | Antinarelli, Luciana Maria Ribeiro | |
dc.contributor.author | Machado, Amanda Sanchez | |
dc.contributor.author | Carvalho, Lívia Mendes | |
dc.contributor.author | Carvalho, Ana Maria Ravena Severino | |
dc.contributor.author | Salustiano, Iorrana Vieira | |
dc.contributor.author | Reis, Thiago Alves Rosa dos | |
dc.contributor.author | Bandeira, Raquel Soares | |
dc.contributor.author | Silva, Alessandra M. | |
dc.contributor.author | Martins, Vivian Tamietti | |
dc.contributor.author | Chávez Fumagalli, Miguel Angel | |
dc.contributor.author | Humbert, Maria Victoria | |
dc.contributor.author | Roatt, Bruno Mendes | |
dc.contributor.author | Duarte, Mariana Costa | |
dc.contributor.author | Souza, Daniel Menezes | |
dc.contributor.author | Coimbra, Elaine Soares | |
dc.contributor.author | Leite, João Paulo Viana | |
dc.contributor.author | Coelho, Eduardo Antônio Ferraz | |
dc.contributor.author | Gonçalves, Denise Utsch | |
dc.date.accessioned | 2021-09-30T16:38:17Z | |
dc.date.available | 2021-09-30T16:38:17Z | |
dc.date.issued | 2020 | pt_BR |
dc.description.abstract | Aims: Treatment for visceral leishmaniasis (VL) is hampered by the toxicity and/or high cost of drugs, as well as by emergence of parasite resistance. Therefore, there is an urgent need for new antileishmanial agents. Methods and Results: In this study, the antileishmanial activity of a diprenylated flavonoid called 5,7,3,4’-tetrahydroxy-6,8-diprenylisoflavone (CMt) was tested against Leishmania infantum and L amazonensis species. Results showed that CMt presented selectivity index (SI) of 70.0 and 165.0 against L infantum and L amazonensis promastigotes, respectively, and of 181.9 and 397.8 against respective axenic amastigotes. Amphotericin B (AmpB) showed lower SI values of 9.1 and 11.1 against L infantum and L amazonensis promastigotes, respectively, and of 12.5 and 14.3 against amastigotes, respectively. CMt was effective in the treatment of infected macrophages and caused alterations in the parasite mitochondria. L infantum-infected mice treated with miltefosine, CMt alone or incorporated in polymeric micelles (CMt/Mic) presented significant reductions in the parasite load in distinct organs, when compared to the control groups. An antileishmanial Th1-type cellular and humoral immune response were developed one and 15 days after treatment, with CMt/Mic-treated mice presenting a better protective response. Conclusion: Our data suggest that CMt/Mic could be evaluated as a chemotherapeutic agent against VL. | pt_BR |
dc.identifier.citation | PEREIRA, I. A. G. et al. Parasitological and immunological evaluation of a novel chemotherapeutic agent against visceral leishmaniasis. Parasite Immunology, v. 42, n. 12, artigo e12784, dez. 2020. Disponível em: <https://onlinelibrary.wiley.com/doi/abs/10.1111/pim.12784>. Acesso em: 10 jun. 2021. | pt_BR |
dc.identifier.doi | https://doi.org/10.1111/pim.12784 | pt_BR |
dc.identifier.issn | 1365-3024 | |
dc.identifier.uri | http://www.repositorio.ufop.br/jspui/handle/123456789/13830 | |
dc.identifier.uri2 | https://onlinelibrary.wiley.com/doi/abs/10.1111/pim.12784 | pt_BR |
dc.language.iso | en_US | pt_BR |
dc.rights | restrito | pt_BR |
dc.subject | Delivery systems | pt_BR |
dc.subject | Flavonoids | pt_BR |
dc.subject | Immune response | pt_BR |
dc.subject | Miltefosine | pt_BR |
dc.subject | Treatment | pt_BR |
dc.title | Parasitological and immunological evaluation of a novel chemotherapeutic agent against visceral leishmaniasis. | pt_BR |
dc.type | Artigo publicado em periodico | pt_BR |
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