Nitrosyl/Diphenylphosphine/Amino Acid–Ruthenium complexes as inhibitors of MDA-MB-231 breast cancer cells.
dc.contributor.author | Barbosa, Marília Imaculada Frazão | |
dc.contributor.author | Correa, Rodrigo de Souza | |
dc.contributor.author | Macedo, Adriana Pereira Mundim Guedes | |
dc.contributor.author | Graça, Alex Marchezini | |
dc.contributor.author | Andrade, Francyelli Mello | |
dc.contributor.author | Leite, Celisnolia Morais | |
dc.contributor.author | Lacerda, Elisângela de Paula Silveira | |
dc.contributor.author | Ellena, Javier Alcides | |
dc.contributor.author | Silva, Henrique Vieira Reis | |
dc.contributor.author | Doriguetto, Antônio Carlos | |
dc.contributor.author | Batista, Alzir Azevedo | |
dc.date.accessioned | 2023-11-24T19:57:41Z | |
dc.date.available | 2023-11-24T19:57:41Z | |
dc.date.issued | 2023 | pt_BR |
dc.description.abstract | Herein, we report on the synthesis and characterization of ruthenium compounds with the general formula [RuCl(AA-H)(NO)(dppb]PF6 , where AA = glycine (1), L-alanine (2), L-phenylalanine (3) and L-valine (4), and dppb = 1,4-bis(diphenylphosphine)butane. The complexes were characterized using elemental analysis, UV/Vis and infrared spectroscopies, 1H, 13C, 31P NMR techniques, and cyclic voltammetry. Furthermore, the structures of the compounds (1) and (3) were determined using single-crystal X-ray diffraction. In vitro evaluation of the Ru(II)/nitrosyl/amino acid complexes revealed their cytotoxic activities against triple-negative MDA-MB-231 breast cancer cells, and against the non-tumor murine fibroblast cells. All the compounds decreased the percentage of viable cells, inducing cell death by apoptosis. Additionally, the Ru(II) complexes inhibited the migration of MDA-MB-231 cells at concentrations lower than 35 µM, after 48 h of exposure. Thus, these complexes may be promising agents for the treatment of triple-negative MDA-MB-231 breast cancer. | pt_BR |
dc.identifier.citation | BARBOSA, M. I. F. et al. Nitrosyl/Diphenylphosphine/Amino Acid–Ruthenium complexes as inhibitors of MDA-MB-231 breast cancer cells. Inorganics, v. 11, n. 7, artigo 270, 2023. Disponível em: <https://www.mdpi.com/2304-6740/11/7/270>. Acesso em: 01 ago. 2023. | pt_BR |
dc.identifier.doi | https://doi.org/10.3390/inorganics11070270 | pt_BR |
dc.identifier.uri | http://www.repositorio.ufop.br/jspui/handle/123456789/17871 | |
dc.language.iso | en_US | pt_BR |
dc.rights | aberto | pt_BR |
dc.rights.license | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). Fonte: PDF do artigo. | pt_BR |
dc.subject | Ruthenium | pt_BR |
dc.subject | Diphenylphosphine | pt_BR |
dc.subject | Amino acids | pt_BR |
dc.subject | Nitric oxide | pt_BR |
dc.subject | Breast cancer cells | pt_BR |
dc.title | Nitrosyl/Diphenylphosphine/Amino Acid–Ruthenium complexes as inhibitors of MDA-MB-231 breast cancer cells. | pt_BR |
dc.type | Artigo publicado em periodico | pt_BR |
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