Tin(IV) compounds derivatives of reaction between Organotin(IV), SNCL4 and rutin trihydrate : characterization and hypolipidemic effects.

Abstract

Equimolar reactions involving SnClPh3, SnCl2Ph2, SnCl3Ph and SnCl4 and rutin trihydrate (Quercetin-3- rutinoside) produced organotin(IV) polymers, which have been characterized by infrared spectroscopy, 'H, n C and "9Sn NMR, Mössbauer spectroscopy, gel permeation chromatography (GPC), differential scanning calorimetry (DSC) and microanalysis. The NMR ('Η, 13C) and "9Sn Mössbauer spectroscopy have revealed dephenylation of the starting organotin(IV) materials. The overall data have revealed a six-coordination for the Sn(IV) centre in solution as well as in solid state. DSC and GPC techniques have confirmed the formation of macromolecules for those adducts with an average molar mass higher than 7.0x10' g/mol. The hypolipidemic effect of total cholesterol reduction in male New Zealand rabbits was comparable to calcic atorvastatin, a commercial drug for treatment of hyperlipidemic patients.