Cytotoxic activity of extracts from Tecoma species and isolated lignans.

dc.contributor.authorReis, Adriana Cotta Cardoso
dc.contributor.authorSilva, Breno de Mello
dc.contributor.authorSouza Filho, José Dias de
dc.contributor.authorPereira, Guilherme Rocha
dc.contributor.authorBrandão, Geraldo Célio
dc.date.accessioned2023-10-10T20:52:16Z
dc.date.available2023-10-10T20:52:16Z
dc.date.issued2022pt_BR
dc.description.abstractA phytochemical study of Tecoma genus (Bignoniaceae) was accomplished by antitumor activity of ethanolic extracts. Species of this genus are composed of small shrubs often used as ornamental plants. The Tecoma stans species is used in folk medicine for different purposes. Recent work shows in vitro anticancer activity against human breast cancer. The ethanolic extracts from leaves and trunks of Tecoma casneifolia, T. garrocha, T. stans var. angustata and T. stans var. stans were tested in vitro. The assays used were against line tumor cells by the MTT method and the most active extracts were further studied. In this way, the ethanolic extract from T. stans var. stans trunks presented the higher cytotoxicity against the tumor cell lines studied (CC50 0.02 to 0.55 μg/ml) when compared to the other extracts tested (CC50 0.08 to 200.0 μg/ml). Accordingly, this extract was selected for chromatographic fractionation from which five known lignans were isolated. Further, paulownin, paulownin acetate, sesamin, olivil and cycloolivil were identified using 13C and 1 H NMR, IR, UV and spectroscopy and spectrometric MS techniques. These isolated compounds were tested and exhibited CC50 ranging from 13.01 to100.0 μg/ml which is superior to the ethanolic extract of trunk of T. stans.pt_BR
dc.identifier.citationREIS, A. C. C. et al. Cytotoxic activity of extracts from Tecoma species and isolated lignans. Brazilian Journal of Pharmaceutical Sciences, v. 58, artigo e181096, 2022. Disponível em: <https://www.scielo.br/j/bjps/a/BxyzcKRW6vkPSZbXm6xN4Bj/>. Acesso em: 01 ago. 2023.pt_BR
dc.identifier.doihttps://doi.org/10.1590/s2175-97902022e181096pt_BR
dc.identifier.issn2175-9790
dc.identifier.urihttp://www.repositorio.ufop.br/jspui/handle/123456789/17550
dc.language.isoen_USpt_BR
dc.rightsabertopt_BR
dc.rights.licenseThis is an open-access article distributed under the terms of the Creative Commons Attribution License. Fonte: PDF do artigo.pt_BR
dc.subjectTecoma castaneifoliapt_BR
dc.subjectTecoma garrochapt_BR
dc.subjectTecoma stanspt_BR
dc.titleCytotoxic activity of extracts from Tecoma species and isolated lignans.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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