Complete assignments of 1h and 13c nmr data for trypanocidal eremantholide c oxide derivatives.
dc.contributor.author | Guimarães, Dênia Antunes Saúde | |
dc.contributor.author | Perry, Katia da Silva Peixoto | |
dc.contributor.author | Raslan, Delio Soares | |
dc.contributor.author | Chiari, Egler | |
dc.contributor.author | Barrero, Alejandro Fernández | |
dc.contributor.author | Oltra, Juan Enrique | |
dc.date.accessioned | 2017-03-10T16:10:24Z | |
dc.date.available | 2017-03-10T16:10:24Z | |
dc.date.issued | 2007 | |
dc.description.abstract | The chemical transformations of eremantholide C (1), a trypanocidal sesquiterpene lactone isolated from Lychnophora trichocarpha Spreng., gave five new oxide derivatives: 3 -hydroxyeremantholide C (2), 1 -formyleremantholide C (3), 1 -carboxyeremantholide C (4), 1 -carbomethoxyeremantholide C (5) and sodium 1 -carboxylate of eremantholide C (6). The 1H and 13C NMR data of all these derivatives were assigned based on 1D and 2D techniques. The derivatives were evaluated against Y and CL strains of Trypanosoma cruzi. All of them were inactive against the Y strain. Compounds 2 and 5 displayed 100% activity on the CL strain while compounds 4 and 6were partially active on the CL strain. Copyright 2007 John Wiley & Sons, Ltd. | pt_BR |
dc.identifier.citation | GUIMARÃES, D. A. S. et al. Complete assignments of 1h and 13c nmr data for trypanocidal eremantholide c oxide derivatives. Agnetic Resonance In Chemistry, v. 45, p.1084-1087, 2007. Disponível em: <http://onlinelibrary.wiley.com/doi/10.1002/mrc.2093/epdf>. Acesso em: 10 jan. 2017. | pt_BR |
dc.identifier.doi | https://doi.org/10.1002/mrc.2093 | |
dc.identifier.issn | 1097-458X | |
dc.identifier.uri | http://www.repositorio.ufop.br/handle/123456789/7353 | |
dc.identifier.uri2 | http://onlinelibrary.wiley.com/doi/10.1002/mrc.2093/epdf | pt_BR |
dc.language.iso | en_US | pt_BR |
dc.rights | restrito | pt_BR |
dc.subject | Lychnophora trichocarpha | pt_BR |
dc.subject | Sesquiterpene lactone | pt_BR |
dc.title | Complete assignments of 1h and 13c nmr data for trypanocidal eremantholide c oxide derivatives. | pt_BR |
dc.type | Artigo publicado em periodico | pt_BR |