High fat diet-induced obesity causes a reduction in brain tyrosine hydroxylase levels and non-motor features in rats through metabolic dysfunction, neuroinflammation and oxidative stress.
dc.contributor.author | Bittencourt, Aline | |
dc.contributor.author | Brum, Pedro Ozorio | |
dc.contributor.author | Ribeiro, Camila Tiefensee | |
dc.contributor.author | Gasparotto, Juciano | |
dc.contributor.author | Bortolin, Rafael Calixto | |
dc.contributor.author | Vargas, Amanda Rodrigues de | |
dc.contributor.author | Heimfarth, Luana | |
dc.contributor.author | Almeida, Roberto Farina de | |
dc.contributor.author | Moreira, José Claudio Fonseca | |
dc.contributor.author | Oliveira, Jade de | |
dc.contributor.author | Gelain, Daniel Pens | |
dc.date.accessioned | 2023-05-10T20:33:45Z | |
dc.date.available | 2023-05-10T20:33:45Z | |
dc.date.issued | 2020 | pt_BR |
dc.description.abstract | Obesity is a health problem that has been associated with neuroinflammation, decreased cognitive functions and development of neurodegenerative diseases. Parkinson’s disease (PD) is a chronic neurodegenerative condition characterized by motor and non-motor abnormalities, increased brain inflammation, α-synuclein protein aggregation and dopaminergic neuron loss that is associated with decreased levels of tyrosine hydroxylase (TH) in the brain. Diet-induced obesity is a global epidemic and its role as a risk factor for PD is not clear. Herein, we showed that 25 weeks on a high-fat diet (HFD) promotes significant alterations in the nigrostriatal axis of Wistar rats. Obesity induced by HFD exposure caused a reduction in TH levels and increased TH phosphorylation at serine 40 in the ventral tegmental area. These effects were associated with insulin resistance, increased tumor necrosis factor-α levels, oxidative stress, astrogliosis and microglia activation. No difference was detected in the levels of α-synuclein. Obesity also induced impairment of locomotor activity, total mobility and anxiety-related behaviors that were identified in the open-field and light/dark tasks. There were no changes in motor coordination or memory. Together, these data suggest that the reduction of TH levels in the nigrostriatal axis occurs through an α-synuclein-independent pathway and can be attributed to brain inflammation, oxidative/nitrosative stress and metabolic disorders induced by obesity. | pt_BR |
dc.identifier.citation | BITTENCOURT, A. et al. High fat diet-induced obesity causes a reduction in brain tyrosine hydroxylase levels and non-motor features in rats through metabolic dysfunction, neuroinflammation and oxidative stress. Nutritional Neuroscience, 2020. Disponível em: <https://www.tandfonline.com/doi/full/10.1080/1028415X.2020.1831261>. Acesso em: 11 out. 2022. | pt_BR |
dc.identifier.doi | https://doi.org/10.1080/1028415X.2020.1831261 | pt_BR |
dc.identifier.issn | 1476-8305 | |
dc.identifier.uri | http://www.repositorio.ufop.br/jspui/handle/123456789/16547 | |
dc.identifier.uri2 | https://www.tandfonline.com/doi/full/10.1080/1028415X.2020.1831261 | pt_BR |
dc.language.iso | en_US | pt_BR |
dc.rights | restrito | pt_BR |
dc.subject | Parkinson’s disease | pt_BR |
dc.subject | Inflammation | pt_BR |
dc.subject | Locomotion | pt_BR |
dc.subject | Anxiety | pt_BR |
dc.title | High fat diet-induced obesity causes a reduction in brain tyrosine hydroxylase levels and non-motor features in rats through metabolic dysfunction, neuroinflammation and oxidative stress. | pt_BR |
dc.type | Artigo publicado em periodico | pt_BR |
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