NAMPT levels are inversely related to nitric oxide formation and positively related to soluble fms-like tyrosine kinase-1 levels in preeclampsia.

dc.contributor.authorPereira, Daniela A.
dc.contributor.authorSandrim, Valeria Cristina
dc.contributor.authorPalei, Ana Carolina Taveiros
dc.contributor.authorSantos, José Eduardo Tanus dos
dc.contributor.authorBelo, Vanessa de Almeida
dc.contributor.authorCavalli, Ricardo de Carvalho
dc.contributor.authorLuizon, Marcelo Rizzatti
dc.date.accessioned2022-12-07T20:15:12Z
dc.date.available2022-12-07T20:15:12Z
dc.date.issued2019pt_BR
dc.description.abstractNAMPT is a biomarker for endothelial dysfunction, but its relationship with nitrite (marker of NO formation) and soluble fms-like tyrosine kinase-1 (sFLT-1) has not been previously evaluated in preeclampsia. Therefore, we measured plasma NAMPT and sFLT-1 levels using enzyme immunoassays and plasma nitrite concentrations using an ozone-based chemiluminescence assay. NAMPT was positively correlated to nitrite (r = 0.217; P = 0.034) and inversely related to sFLT-1 (r = −0.340; P = 0.029) in healthy pregnant women, but inversely related to nitrite (r = −0.259; P = 0.035) and positively correlated to sFLT-1 (r = 0.326; P = 0.007) in pre- eclamptic patients, suggesting that NAMPT inhibits NO formation and interacts with the antiangiogenic factor sFLT-1 in preeclampsia.pt_BR
dc.identifier.citationPEREIRA, D. A. et al. NAMPT levels are inversely related to nitric oxide formation and positively related to soluble fms-like tyrosine kinase-1 levels in preeclampsia. Pregnancy Hypertension, v. 18, p. 137-140, 2019. Disponível em: <https://www.sciencedirect.com/science/article/pii/S2210778919304489?via%3Dihub>. Acesso em: 11 out. 2022.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.preghy.2019.09.022pt_BR
dc.identifier.issn2210-7789
dc.identifier.urihttp://www.repositorio.ufop.br/jspui/handle/123456789/15879
dc.identifier.uri2https://www.sciencedirect.com/science/article/pii/S2210778919304489?via%3Dihubpt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subjectNicotinamide phosphorybosil transferasept_BR
dc.subjectNitrite levelspt_BR
dc.subjectPreeclampsiapt_BR
dc.subjectVisfatin / NAMPTpt_BR
dc.titleNAMPT levels are inversely related to nitric oxide formation and positively related to soluble fms-like tyrosine kinase-1 levels in preeclampsia.pt_BR
dc.typeArtigo publicado em periodicopt_BR

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