Mapping of brain activity in the analgesia induced by Phα1β and morphine.
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2022
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Resumo
Preclinical evidence suggests the potential of Phα1β, a toxin obtained from the venom of
spider Phoneutria nigriventer, as a new analgesic drug. Molecular brain imaging
techniques have afforded exciting opportunities to examine brain processes in clinical
pain conditions. This paper aims to study the brain regions involved in the analgesic effects
of Phα1β compared with Morphine, in a model of acute pain induced by formalin in
Sprague Dawley rats. We used 18F-fluorodeoxyglucose as a metabolic radiotracer to
perform brain imaging of rats pretreated with Phα1β or Morphine in a model of acute
inflammatory pain caused by intraplantar injection of formalin. The rats’ hind paw’s formalin
stimulation resulted in a brain metabolic increase at the bilateral motor cortex, visual cortex,
somatosensory cortex, thalamus, and cingulate cortex.In rats treated with Phα1β, selective
inhibition of unilateral motor cortex and cingulate cortex was observed. Morphine
treatment leads to small and selective inhibition at the bilateral amygdala striatum and
accumbens. Our results indicate that the analgesic effect of Phα1β and Morphine
possesses a differential profile of central processing in the pain state.
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Pain
Citação
DINIZ, D. M. et al. Mapping of brain activity in the analgesia induced by Phα1β and morphine. Frontiers in Molecular Biosciences, v. 8, fev. 2022. Disponível em: <https://www.frontiersin.org/articles/10.3389/fmolb.2021.770471/full>. Acesso em: 11 out. 2022.