Comparison of the efficacy of losartan, hydrocortisone and acetylsalicylic acid (ASA) in preventing the development of fibrous scar tissue in skeletal muscle.
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2018
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Objective: To analyze fibrous scar tissue inhibition capacity with the use of losartan, hydrocortisone and
acetylsalicylic acid. Method: The sample consisted of 120 male heterogeneic Wistar rats with a muscle laceration
model. The rats were divided into four groups of 30 animals each: control group, losartan group, ASA group and
hydrocortisone group. The animals were anesthetized and a 2.5 cm longitudinal incision was made in the left
thoracolumbar paravertebral region. The muscles were subjected to a Grade III lesion caused by applying Kelly
hemostatic forceps for 60 seconds, followed by sectioning with scissors. The skin was sutured with 3-0 nylon
monofilament thread. The animals were placed in individual cages with plenty of food and water. The losartan
group received losartan diluted in water at a dose of 0.1 mg/mL (10 mg/kg/day), the ASA Group received a 3
mg/mL ASA solution (300 mg/kg/day), and the hydrocortisone group received a 0.2 mg/mL hydrocortisone
solution (20 mg/kg/day). Results: The control, losartan, hydrocortisone and aspirin groups had a fibrotic area of
0.95 ± 0.35 mm, 0.55 ± 0.34 mm, 0.93 ± 0.33 mm, and 0.66 ± 0.36 mm, respectively. We observed a significantly
smaller fibrotic area in the losartan group compared to the control (p=0.01) and hydrocortisone (p=0.01) groups.
There were no significant differences among the other groups. Conclusion: The healing of striated skeletal
muscle produced less fibrous scar tissue when exposed to losartan in comparison to the control group or the
hydrocortisone group. Level of Evidence I; Randomized double-blind placebo-controlled study.
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Regeneration, Transforming growth factor beta, Satellite cells, Striated
Citação
SILVA JÚNIOR, O. de M. et al. Comparison of the efficacy of losartan, hydrocortisone and acetylsalicylic acid (ASA) in preventing the development of fibrous scar tissue in skeletal muscle. Revista Brasileira de Medicina do Esporte, São Paulo, v. 24, n. 6, p. 418-421, nov./dez. 2018. Disponível em: <http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1517-86922018000600418&lng=en&nrm=iso>. Acesso em: 25 fev. 2019.