Himatanthus bracteatus stem extracts present antiflavivirus activity while an isolated sesquiterpene glucoside present only anti-Zika virus activity in vitro.

Resumo

The hexane and ethanol extracts from Himatanthus bracteatus (Apocynaceae) stems were evaluated for antiviral activity against Zika virus, yellow fever virus and dengue virus 2 and for cytotoxicity in Vero cells by MTT assay. The ethanol extract showed good antiviral activity against the three viruses with selective indexes (SI) > 10 and its fractionation led to the isolation of the known plumieride that was active only against Zika virus (SI of 15.97).

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Yellow fever virus, Plumieride, Spectroscopic analyses

Citação

SILVA, M. L. et al. Himatanthus bracteatus stem extracts present antiflavivirus activity while an isolated sesquiterpene glucoside present only anti-Zika virus activity in vitro. Natural Product Research, nov. 2019. Disponível em: <https://www.tandfonline.com/doi/full/10.1080/14786419.2019.1690487>. Acesso em: 10 fev. 2020.

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