Variation in susceptibility to benznidazole in isolates derived from Trypanosoma cruzi parental strains.
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Data
2001
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In this work, the susceptibility to benznidazole of two parental Trypanosoma cruzi strains, Colombian
and Berenice-78, was compared to isolates obtained from dogs infected with these strains for
several years. In order to evaluate the susceptibility to benznidazole two groups of mice were infected
with one of five distinct populations isolated from dogs as well as the two parental strains of T. cruzi.
The first group was treated with benznidazole during the acute phase and the second remained untreated
controls. The animals were considered cured when parasitological and serological tests remained
persistently negative. Mice infected with the Colombian strain and its isolates Colombian (A
and B) did not cure after treatment. On the other hand, all animals infected with Berenice-78 were
cured by benznidazole treatment. However, 100%, 50% and 70% of cure rates were observed in animals
infected with the isolates Berenice-78 B, C and D, respectively. No significant differences were observed
in serological profile of infected control groups, with all animals presenting high antibody levels.
However, the ELISA test showed differences in serological patterns between mice inoculated with the
different T. cruzi isolates and treated with benznidazole. This variability was dependent on the T. cruzi
population used and seemed to be associated with the level of resistance to benznidazole.
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Chemotherapy, Drug susceptibility
Citação
VELOSO, V. M. et al. Variation in susceptibility to benznidazole in isolates derived from Trypanosoma cruzi parental strains. Memórias do Instituto Oswaldo Cruz, v. 96, n. 7, p.1005-1011, 2001. Disponível em: <http://www.scielo.br/pdf/mioc/v96n7/4215.pdf>. Acesso em: 10 jan. 2017.