Dengue infection susceptibility of five Aedes aegypti populations from Manaus (Brazil) after challenge with Virus Serotypes 1-4.
dc.contributor.author | Chaves, Bárbara Aparecida | |
dc.contributor.author | Godoy, Raquel Soares Maia | |
dc.contributor.author | Campolina, Thaís Bonifácio | |
dc.contributor.author | Vieira Junior, Ademir Bentes | |
dc.contributor.author | Paz, Andréia da Costa | |
dc.contributor.author | Vaz, Evelyn Beatriz da Costa | |
dc.contributor.author | Silva, Breno de Mello | |
dc.contributor.author | Nascimento, Rêgila Mello | |
dc.contributor.author | Guerra, Maria das Graças Vale Barbosa | |
dc.contributor.author | Lacerda, Marcus Vinícius Guimarães de | |
dc.contributor.author | Monteiro, Wuelton Marcelo | |
dc.contributor.author | Secundino, Nagila Francinete Costa | |
dc.contributor.author | Pimenta, Paulo Filemon Paolucci | |
dc.date.accessioned | 2023-03-21T21:49:49Z | |
dc.date.available | 2023-03-21T21:49:49Z | |
dc.date.issued | 2022 | pt_BR |
dc.description.abstract | The successful spread and maintenance of the dengue virus (DENV) in mosquito vectors depends on their viral infection susceptibility, and parameters related to vector competence are the most valuable for measuring the risk of viral transmission by mosquitoes. These parameters may vary according to the viral serotype in circulation and in accordance with the geographic origin of the mosquito population that is being assessed. In this study, we investigated the effect of DENV serotypes (1–4) with regards to the infection susceptibility of five Brazilian Ae. aegypti populations from Manaus, the capital of the state of Amazonas, Brazil. Mosquitoes were challenged by oral infection with the DENV serotypes and then tested for the presence of the arbovirus using quantitative PCR at 14 days post-infection, which is the time point that corresponds to the extrinsic incubation period of Ae. aegypti when reared at 28 ◦C. Thus, we were able to determine the infection patterns for DENV-1, -2, -3 and -4 in the mosquito populations. The mosquitoes had both interpopulation and inter-serotype variation in their viral susceptibilities. All DENV serotypes showed a similar tendency to accumulate in the body in a greater amount than in the head/salivary gland (head/SG), which does not occur with other flaviviruses. For DENV-1, DENV-3, and DENV-4, the body viral load varied among populations, but the head/SG viral loads were similar. Differently for DENV-2, both body and head/SG viral loads varied among populations. As the lack of phenotypic homogeneity represents one of the most important reasons for the long-term fight against dengue incidence, we expect that this study will help us to understand the dynamics of the infection patterns that are triggered by the distinct serotypes of DENV in mosquitoes. | pt_BR |
dc.identifier.citation | CHAVES, B. A. et al. Dengue infection susceptibility of five Aedes aegypti populations from Manaus (Brazil) after challenge with Virus Serotypes 1-4. Viruses, v. 14, n. 1, artigo 20, 2022. Disponível em: <https://www.mdpi.com/1999-4915/14/1/20>. Acesso em: 11 out. 2022. | pt_BR |
dc.identifier.doi | https://doi.org/10.3390/v14010020 | pt_BR |
dc.identifier.issn | 1999-4915 | |
dc.identifier.uri | http://www.repositorio.ufop.br/jspui/handle/123456789/16399 | |
dc.language.iso | en_US | pt_BR |
dc.rights | aberto | pt_BR |
dc.rights.license | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). Fonte: o PDF do artigo. | pt_BR |
dc.subject | Antiviral response | pt_BR |
dc.subject | Mosquito population | pt_BR |
dc.subject | Vector-borne disease | pt_BR |
dc.subject | Vector competence | pt_BR |
dc.subject | Infection rate | pt_BR |
dc.title | Dengue infection susceptibility of five Aedes aegypti populations from Manaus (Brazil) after challenge with Virus Serotypes 1-4. | pt_BR |
dc.type | Artigo publicado em periodico | pt_BR |
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