Cardiac changes in spontaneously hypertensive rats : modulation by aerobic exercise.
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2023
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Resumo
Systemic arterial hypertension is a multifactorial clinical condition characterized by high and sustained levels of
blood pressure. For a better understanding of the pathophysiology of hypertension, studies are conducted with
spontaneously hypertensive animals, which allow the investigation of physiological changes that in most cases
cannot be studied in humans. In these animals, myocardial remodeling, increased pro-inflammatory markers,
redox imbalance and contractile dysfunctions that lead to changes in cardiac function can be observed. However,
it can be inferring that aerobic training improves cardiac function and cardiomyocyte contractility, in addition to
controlling inflammation and reducing oxidative stress in cardiac muscle, despite this, the precise mechanisms by
which physical exercise improves cardiovascular control are not fully understood. In this review, we provide an
overview of the pathophysiological changes that affect the heart of spontaneously hypertensive animals and their
modulation by aerobic exercise.
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Hypertension, Aerobic exercise, Oxidative stress, Inflammation, Cardiac hypertrophy
Citação
TELES, M. C. et al. Cardiac changes in spontaneously hypertensive rats : modulation by aerobic exercise. Progress in Biophysics & Molecular Biology, v. 175, p. 109-124, jan. 2023. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0079610722001171>. Acesso em: 01 ago. 2023.