In vitro activity of 2-pyridinecarboxylic acid against trypanosomes of the subgenus Schizotrypanum isolated from the bat Phyllostomus hastatus.
Nenhuma Miniatura Disponível
Data
2011
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
The effect of 2-pyridinecarboxylic acid (picolinic acid) on trypanosomes of the subgenus Schizotrypanum isolated from the bat Phyllostomus hastatus was determined in this study. Picolinic acid, at 50 g mL-1, inhibited epimastigote growth by 99% after 12 days incubation. In addition, trypomastigote motility decreased by 50% after 6h and completely after 24h in the presence of 50 g mL-1 picolinic acid. The 50% cytotoxic concentration on HEp-2 cell line was 275 g mL-1 after 4 days incubation. Altogether, these results indicate higher toxicity against trypanosomes. The inhibitory effect of picolinic acid on epimastigote growth can be partially reversed by nicotinic acid and L tryptophan, suggesting a competitive inhibition. Furthermore, two anti-Trypanosoma (Schizotrypanum) cruzi drugs were also evaluated with regard to bat trypanosome growth. Benznidazole, at 50 g mL-1, inhibited epimastigote growth by 90% after 12 days incubation. Nifurtimox, at the same concentration, caused 96% growth inhibition after four days incubation. Corroborating a previous study, bat trypanosomes are a good model for screening new trypanocidal compounds. Moreover, they can be used to study many biological processes common to human pathogenic trypanosomatids.
Descrição
Palavras-chave
Bat trypanosome, Schizotrypanum, Antimicrobial activity
Citação
CORRÊA, P. R. et al. In vitro activity of 2-pyridinecarboxylic acid against trypanosomes of the subgenus Schizotrypanum isolated from the bat Phyllostomus hastatus. Acta Scientiarum. Biological Sciences, v. 33, n. 4, p. 437-443, 2011. Disponível em: <http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/6482>. Acesso em: 20 ago. 2014.