Synthesis and antimicrobial activity of molecular hybrids based on eugenol and chloramphenicol pharmacophores.
dc.contributor.author | Oliveira, Lucas Martins | |
dc.contributor.author | Siqueira, Fallon dos Santos | |
dc.contributor.author | Silva, Michelle T. | |
dc.contributor.author | Machado, José Vaz Cardoso | |
dc.contributor.author | Cordeiro, Cleydson Finotti | |
dc.contributor.author | Diniz, Lívia de Figueiredo | |
dc.contributor.author | Campos, Marli Matiko Anraku de | |
dc.contributor.author | Franco, Lucas Lopardi | |
dc.contributor.author | Souza, Thiago Belarmino de | |
dc.contributor.author | Hawkes, Jamie Anthony | |
dc.contributor.author | Carvalho, Diogo Teixeira | |
dc.date.accessioned | 2023-10-18T17:42:27Z | |
dc.date.available | 2023-10-18T17:42:27Z | |
dc.date.issued | 2023 | pt_BR |
dc.description.abstract | In the constant search for new pharmacological compounds, molecular hybridisation is a well-known technique whereby two or more known pharmacophoric subunits are combined to create a new “hybrid” compound. This hybrid is expected to maintain the characteristics of the original compounds whilst demonstrating improvements to their pharmacological action. Accordingly, we report here a series of molecular hybrid compounds based upon eugenol and chloramphenicol pharmacophores. The hybrid compounds were screened for their in vitro antimicrobial potential against Gram-negative and Gram-positive bacteria and also rapidly growing mycobacteria (RGM). The results highlight that the antimicrobial profiles of the hybrid compounds improve in a very clear fashion when moving through the series. The most prominent results were found when comparing the activity of the hybrid compounds against some of the multidrug-resistant clinical isolates of Pseudomonas aeruginosa, methicillin-resistant clinical isolates of Staphylococcus aureus (MRSA) and clinical isolates of rapidly growing mycobacteria. | pt_BR |
dc.identifier.citation | OLIVEIRA, L. M. et al. Synthesis and antimicrobial activity of molecular hybrids based on eugenol and chloramphenicol pharmacophores. Folia Microbiologica, abr. 2023. Disponível em: <https://link.springer.com/article/10.1007/s12223-023-01057-9>. Acesso em: 01 ago. 2023. | pt_BR |
dc.identifier.doi | https://doi.org/10.1007/s12223-023-01057-9 | pt_BR |
dc.identifier.issn | 1874-9356 | |
dc.identifier.uri | http://www.repositorio.ufop.br/jspui/handle/123456789/17599 | |
dc.identifier.uri2 | https://link.springer.com/article/10.1007/s12223-023-01057-9 | pt_BR |
dc.language.iso | en_US | pt_BR |
dc.rights | restrito | pt_BR |
dc.subject | Hybridisation | pt_BR |
dc.subject | Rapidly growing mycobacteria | pt_BR |
dc.title | Synthesis and antimicrobial activity of molecular hybrids based on eugenol and chloramphenicol pharmacophores. | pt_BR |
dc.type | Artigo publicado em periodico | pt_BR |
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