Field randomized trial to evaluate the efficacy of the Leish - Tec vaccine against canine visceral leishmaniasis in anendemic area of Brazil.
dc.contributor.author | Silva, Shara Regina | |
dc.contributor.author | Feres, Ana Maria Leonardi Tibúrcio | |
dc.contributor.author | Silva, João Carlos França da | |
dc.contributor.author | Dias, Edelberto Santos | |
dc.contributor.author | Michalsky, Érika Monteiro | |
dc.contributor.author | Andrade, Hélida Monteiro de | |
dc.contributor.author | Coelho, Eduardo Antônio Ferraz | |
dc.contributor.author | Ribeiro, Gustavo Meirelles | |
dc.contributor.author | Fernandes, Ana Paula Salles Moura | |
dc.contributor.author | Coelho, George Luiz Lins Machado | |
dc.date.accessioned | 2016-07-22T16:05:50Z | |
dc.date.available | 2016-07-22T16:05:50Z | |
dc.date.issued | 2016 | |
dc.description.abstract | Background: A canine vaccine remains a promising approach for effective control of visceral leishmaniasis(VL), given its complex epidemiology in areas where zoonotic VL is prevalent. Leish-Tec®is a recombi-nant vaccine, based on the Leishmania A2 antigen, against canine VL (CVL). It is, since 2014, the singlecommercial vaccine licensed in Brazil. Here, Leish-Tec®efficacy was estimated through a randomizedfield trial (RFT), in a highly VL endemic area.Methods: The RFT was conducted from 2008 to 2010 in an endemic area of southeastern Brazil, presentinga CVL seroprevalence of 41.9%. Eight hundred forty-seven seronegative dogs were randomly selected toreceive Leish-Tec®(n = 429) or placebo (n = 418). Animals were followed up by clinical, serological, andparasitological exams for 18 months. The CVL incidence in both groups was compared through proportionanalysis.Results: A significant reduction in the number of cases of CVL was observed in the vaccine group, ascompared with the placebo group, whether efficacy was estimated according to parasitological results(71.4%; 95% CI: 34.9–87.3%; p = 0.001; risk ratio = 0.287), by adding results of xenodiagnosis and parasito-logical exams (58.1%; 95% CI: 26.0–76.3%; p = 0.002; risk ratio = 0.419). Among the animals that convertedto a positive anti-A2 serology, efficacy reached 80.8% (95% CI: 37.6–94.1%, p = 0.001; risk ratio = 0.192).Xenodiagnosis has detected a reduction of 46.6% (p = 0.05) in transmission to sand flies from vaccinatedanimals presenting anti-A2 positive serology.Conclusion: The Leish-Tec®vaccine proved significantly effective for prophylaxis of CVL, after naturalchallenge assured by transmission of Leishmania parasites, in a highly endemic area. Noteworthy, thisreport has unveiled the complexity of performing a RFT for anti-CVL vaccines in Brazil, which may behelpful for designing of future studies. | pt_BR |
dc.identifier.citation | SILVA, S. R. et al. Field randomized trial to evaluate the efficacy of the Leish - Tec vaccine against canine visceral leishmaniasis in anendemic area of Brazil. Vaccine (Guildford), v. 34, p. 2233-2239, 2016. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0264410X16003303>. Acesso em: 16 jun. 2016. | pt_BR |
dc.identifier.doi | https://doi.org/10.1016/j.vaccine.2016.03.019 | |
dc.identifier.issn | 0264-410X | |
dc.identifier.uri | http://www.repositorio.ufop.br/handle/123456789/6596 | |
dc.language.iso | en_US | pt_BR |
dc.rights | aberto | pt_BR |
dc.rights.license | O periódico Vaccine concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3894171189856. | |
dc.subject | Randomized field trial | pt_BR |
dc.subject | Canine visceral leishmaniasis | pt_BR |
dc.subject | Vaccine | pt_BR |
dc.subject | Efficacy | pt_BR |
dc.title | Field randomized trial to evaluate the efficacy of the Leish - Tec vaccine against canine visceral leishmaniasis in anendemic area of Brazil. | pt_BR |
dc.type | Artigo publicado em periodico | pt_BR |
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