Lactobacillus delbrueckii UFV-H2b20 increases IFN-γ production and CD39+CD73+ Treg cell numbers in lungs, and protects mice against experimental allergic asthma.
Nenhuma Miniatura Disponível
Data
2022
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
Asthma is a disorder characterized by airflow obstruction, inflammation, declining airway function, bronchial
hyperresponsiveness and tissue remodelling. Probiotics are defined as “live microorganisms that, when administered in adequate amounts, confer a health benefit on the host”. The use of probiotics is becoming increasingly
studied and recent evidence has suggested that it may provide therapeutic benefits in asthma and other diseases.
Lactobacillus delbrueckii UFV-H2b20 fulfils all the requirements to be classified as probiotic. Previous studies have
already shown the ability of L. delbrueckii UFV-H2b20 to stimulate the immune system. Our objective was to
evaluate the protective effects of L. delbrueckii UFV-H2b20 in experimental allergic asthma. We used a murine
model of ovalbumin-induced allergic airway inflammation to mimic allergic asthma. Oral treatment with
L. delbrueckii UFV-H2b20 improves respiratory parameters and inhibits the inflammatory response in the lungs
by decreasing the numbers of inflammatory monocytes, eosinophils and alveolar macrophages, as well as IgE
levels. Treatment increased the IFN-γ/IL-4 cytokine ratio. Levels of IL-10 in the lungs were also increased in
treated animals. Our results also showed that the probiotic administration increases the number of CD39+CD73+
T regulatory lymphocytes in the lung, suggesting a role for purinergic signals in the regulation of inflammation
promoted by the treatment. Understanding the mechanisms of modulation of the immune system by probiotics
could allow the development of probiotic preparations that are safe and have a direct action. Our results suggest
that oral administration of L. delbrueckii UFV-H2b20 could be helpful to treat chronic inflammatory airway
diseases, such as asthma.
Descrição
Palavras-chave
Probiotic, Lung allergy, Immunoregulation
Citação
ANDRADE, A. C. M. M. de et al. Lactobacillus delbrueckii UFV-H2b20 increases IFN-γ production and CD39+CD73+ Treg cell numbers in lungs, and protects mice against experimental allergic asthma. Immunobiology, v. 227, n. 6, artigo 152284, nov. 2022. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0171298522001103?via%3Dihub>. Acesso em: 01 ago. 2023.