Benznidazole microcrystal preparation by solvent change precipitation and in vivo evaluation in the treatment of Chagas disease.
dc.contributor.author | Maximiano, Flávia Pires | |
dc.contributor.author | Paula, Lívia Maria de | |
dc.contributor.author | Figueiredo, Vivian Paulino | |
dc.contributor.author | Andrade, Isabel Mayer de | |
dc.contributor.author | Silva, André Talvani Pedrosa da | |
dc.contributor.author | Barreto, Lívia Cristina Lira de Sá | |
dc.contributor.author | Bahia, Maria Terezinha | |
dc.contributor.author | Cunha Filho, Marcílio Sérgio Soares da | |
dc.date.accessioned | 2015-01-28T19:55:18Z | |
dc.date.available | 2015-01-28T19:55:18Z | |
dc.date.issued | 2011 | |
dc.description.abstract | Benznidazole (BNZ) is traditionally used to treat Chagas disease. Despite its common use, BNZ has a poor water solubility and a variable bioavailability. The purpose of this study was to prepare BNZ microcrystals by solvent change precipitation and to study the effects of BNZ micronisation on therapeutic efficiency using a murine model of Chagas disease. The solvent change precipitation procedure was optimised in order to obtain stable and homogeneous particles with a small particle size, high yield and fast dissolution rate. The thermal and crystallographic analysis showed no polymorphic change in the microcrystals, and microscopy confirmed a significant reduction in particle size. A marked improvement in the drug dissolution rate was observed for micronised BNZ particles and BNZ tablets in comparison with untreated BNZ and commercial Rochagan_. In vivo studies showed a significant increase in the therapeutic efficacy of the BNZ microparticles, corroborating the dissolution results. | pt_BR |
dc.identifier.citation | MAXIMIANO, F. P. et al. Benznidazole microcrystal preparation by solvent change precipitation and in vivo evaluation in the treatment of Chagas disease. European Journal of Pharmaceutics and Biopharmaceutics, v. 78, p. 377-384, 2011. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0939641111000877>. Acesso em: 08 nov. 2014. | pt_BR |
dc.identifier.doi | https://doi.org/10.1016/j.ejpb.2011.03.003 | |
dc.identifier.issn | 0939-6411 | |
dc.identifier.uri | http://www.repositorio.ufop.br/handle/123456789/4418 | |
dc.language.iso | en_US | pt_BR |
dc.rights.license | O periódico European Journal of Pharmaceutics and Biopharmaceutics concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3517690950523. | pt_BR |
dc.subject | Benznidazole | pt_BR |
dc.subject | Chagas disease | pt_BR |
dc.subject | Solvent change precipitation | pt_BR |
dc.subject | Dissolution rate | pt_BR |
dc.subject | Microcrystals | pt_BR |
dc.title | Benznidazole microcrystal preparation by solvent change precipitation and in vivo evaluation in the treatment of Chagas disease. | pt_BR |
dc.type | Artigo publicado em periodico | pt_BR |
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