DEFAR - Departamento de Farmácia
URI permanente desta comunidadehttp://www.hml.repositorio.ufop.br/handle/123456789/530
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2 resultados
Resultados da Pesquisa
Item A new Brazilian regional scenario of Type 2 diabetes risk in the next ten years.(2021) Nascimento, Lúbia Guaima; Nascimento, Renata Cristina Rezende Macedo do; Frade, Josélia Cintya Quintão Pena; Pinheiro, Eliete Bachrany; Ferreira, Wesley Magno; Reis, Janice Sepúlveda; Melo, Karla Fabiana Santana de; Pontarolo, Roberto; Lenzi, Mônica Soares Amaral; Almeida, José Vanilton de; João, Walter Jorge; Pedrosa, Hermelinda Cordeiro; Correr, Cassyano Januário; Vital, Wendel CouraAims: According to a recent national diabetes screening performed by our group in 2018, 18.4% of the Brazilians were found to have high blood glucose. The objective of the present study was to estimate the risk of developing type 2 DM (T2DM) in the next ten years in Brazilian population. Methods: A cross-sectional study was carried out in community pharmacies across Brazil, in 2018, where pharmacists applied the FINDRISC questionnaire to estimate the population’s risk of developing T2DM within a ten-year period. Results: The study included 977 pharmacists from 345 municipalities distributed across the five geograph- ical regions of Brazil. Of the 17,580 people evaluated, the South region was found to have the highest frequency (59.6%) among people at very low and/or low risk of developing T2DM, while the North region, the most underserved, presented the highest and/or very highest T2DM risk (24.1%). The factors that mostly and importantly impacted these regional differences were body mass index; the highest daily consumption of vegetables and fruits; history of high blood glucose and family history of T1DM/T2DM. Conclusion: These results showed an impressive change of direction concerning diabetes numbers between the most underserved region in public health care and one of the most developed and best organized regions concerning health assistance, the North and the South, respectively.Item Outbreaks of cholera-like diarrhoea caused by enterotoxigenic escherichia coli in the Brazilian Amazon rainforest.(2005) Vicente, Ana Carolina Paulo; Teixeira, Luiz Fernando de Medeiros; Iniguez Rojas, Luiza; Gomes, Maria das Graças de Luna; Silva, Luciete Almeida; Andrade, João Ramos Costa; Guth, Beatriz Ernestina CabilioThe relationship between enteropathogens and severe diarrhoea in the Brazilian Amazon is poorly understood. In 1998, outbreaks of acute diarrhoea clinically diagnosed as cholera occurred in two small villages localized far from the main cholera route in the Brazilian rainforest. PCR was performed on some enteropathogens and heat-labile (LT) and/or heat-stable (STh) toxin genes, the virulence determinants of enterotoxigenic Escherichia coli (ETEC), were detected. Further characterization of ETEC isolates revealed the presence of two clones, one from each outbreak. One presenting serotype O167:H5 harboured LT-I and STh toxin genes and expressed the CS5CS6 colonization factor. The other, a non-typeable serotype, was positive for the LT-I gene and expressed the CS7 colonization factor. The current study demonstrates the importance of molecular diagnosis in regions such as the Amazon basin, where the enormous distances and local support conditions make standard laboratory diagnosis difficult. Here we also show that the mis-identified cholera cases were in fact associated with ETEC strains. This is the first report of ETEC, molecularly characterized as the aetiological agent of severe diarrhoea in children and adults in the Brazilian Amazon Rainforest. © 2005 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.