DEFAR - Departamento de Farmácia

URI permanente desta comunidadehttp://www.hml.repositorio.ufop.br/handle/123456789/530

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2009 - 200912020 - 20231

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Assunto: search.filters.subject.Arterial hypertension

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    Angiotensin‐converting enzyme gene (ACE) polymorphisms are associated with dysregulation of biochemical parameters in hypertensive patients.
    (2023) Agostini, Lívia da Cunha; Cunha, Warlley Rosa; Silva, Nayara Nascimento Toledo; Melo, André Sacramento; Soares, Luciana Bicalho Moreira; Almeida, Tamires Cunha; Belo, Vanessa de Almeida; Vital, Wendel Coura; Teixeira, Luiz Fernando de Medeiros; Lima, Angélica Alves; Silva, Glenda Nicioli da
    Introduction The genetic component, including genes and their variants, plays a signifcant role in the pathophysiology of arterial hypertension (AH). Thus, clinical, epidemiological and genetic studies have been carried out to improve the under- standing of disease mechanisms, improve diagnostic quality and contribute to prevention. Objective To determine the association of risk factors, biochemical parameters and diferent ACE gene polymorphisms with AH. Method The case-control study was carried out in the population of Ouro Preto, Brazil. The subjects answered a question- naire containing clinical and sociodemographic data. The ACE gene polymorphisms rs4291, rs4363 and rs4335 were evalu- ated by real time-polymerase chain reaction (real-time PCR) in 310 people (155 hypertensive and 155 normotensive patients), in addition to biochemical parameters. A multivariate logistic regression model was used to identify factors associated with AH. Analysis of continuous variables was performed using the Kruskal-Wallis test to assess signifcance between groups and Dunn’s post-test for multiple comparisons. Results The results showed that AH was associated with age, education, smoking, obesity and high levels of triglycerides, sodium, glucose and uric acid. Regarding the biochemical parameters, in hypertensive patients, the rs4363 and rs4335 poly- morphisms were associated with high levels of triglycerides, urea and glucose; the rs4291 polymorphism was associated with elevated urea and glucose levels. No association was detected between SNPs and HA. Conclusion AH was associated with socioeconomic status, lifestyle habits and biochemical parameters. ACE polymorphisms may have infuenced the levels of triglycerides, urea and glucose in hypertensive patients.
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    Cardiovascular risk factors in children and adolescents living in an urban area of southeast of Brazil : Ouro Preto study.
    (2009) Cândido, Ana Paula Carlos; Benedetto, Raquel; Castro, Ana Paula Pereira; Carmos, Joseane Souza do; Nicolato, Roney Luiz de Carvalho; Nascimento Neto, Raimundo Marques do; Freitas, Renata Nascimento de; Freitas, Silvia Nascimento de; Caiaffa, Waleska Teixeira; Coelho, George Luiz Lins Machado
    This study aims to identify risk factors for cardiovascular disorders in schoolchildren living in Ouro Preto City, Brazil. A cross-sectional study was carried out in a population-based sampling of schoolchildren (6– 14 years old), randomly selected and stratified by the proportion of students according to age and gender in each schools of the city. Biochemical, clinical and anthropometric variables as well as physical activity and family history were used in a logistic regression model for obesity or arterial hypertension. Out of 780 schoolchildren sampled, the risk of obesity was greater in subjects presenting high triglyceride and low high density lipoprotein-cholesterol levels, and those whose parents were obese, whilst the risk of hypertension was high in obese subjects and those who presented low birth weight. It was observed that 44.4% of the schoolchildren were exposed to two or three cardiovascular disease (CVD) risk factors and 8.2% were exposed to four or six factors. These findings should be considered in preventive measures to reduce the future risk for CVD among schoolchildren in Brazil.