DEFAR - Departamento de Farmácia

URI permanente desta comunidadehttp://www.hml.repositorio.ufop.br/handle/123456789/530

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2017 - 20192

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Assunto: search.filters.subject.Antioxidant activity

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    Photoprotective activity and increase of SPF in sunscreen formulation using lyophilized red propolis extracts from Alagoas.
    (2019) Almeida, Wanessa Aparecida da Silveira; Antunes, Amanda dos Santos; Penido, Ricardo Gonçalves; Correa, Helen Silva da Gloria; Nascimento, Andréa Mendes do; Andrade, Ângela Leão; Santos, Vagner Rodrigues; Cazati, Thiago; Amparo, Tatiane Roquete; Souza, Gustavo Henrique Bianco de; Freitas, Katia Michelle; Santos, Orlando David Henrique dos; Sousa, Lucas Resende Dutra; Santos, Viviane Martins Rebello dos
    The excessive sun exposure, coupled with lack of sun protection represents one of the biggest risks to the occurrence of skin cancer and photoaging. Recent strategies for photoprotection have included the incorporation of natural antioxidant and anti-inflammatory compounds, into sunscreens, and the oral administration of natural antioxidant extracts. In this work, we use Brazilian red propolis extract because its antioxidant and anti-inflammatory activities. The aim of this work was to evaluate the sun protection factor and antioxidant activity of different hydroalcoholic extracts of red propolis (70% and 75%) prepared from lyophilized red propolis at room and high temperatures. The sun protection factor in vitro was determined by a spectrophotometric method developed by Mansur. The hydroalcoholic extracts of red propolis incorporated with Filter UVA-UVB 5% Gel Permulem TR-1 presented absorption in the UVB region. Also, the in vitro capacity of the hydroalcoholic extracts of red propolis to increase photoprotective activity of Filter UVA-UVB 5% Gel was evaluated. The hydroalcoholic extracts of red propolis incorporated presented higher values of sun protection factor and showed synergism in the photoprotective activity of Filter UVA-UVB 5% Gel Permulem TR-1. The antioxidant activity and sun protection factor are correlated with total phenolics content of the extracts and the hydroalcoholic extract of red propolis 75% at room temperature was choosen. The formulation developed with Filter UVA-UVB 5% Gel Permulem TR-1 with this hydroalcoholic extract of red propolis showed safe to be applied on the skin according HET-CAM test. Suggests indication of hydroalcoholic extract of red propolis (75% – room temperature) associated to photoprotective formulations for use in photoprotective products.
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    Physicochemical characteristics of Brazilian green propolis evaluated during a six-year period.
    (2017) Figueiredo, Sônia Maria de; Binda, Nancy Scardua; Vieira Filho, Sidney Augusto; Almeida, Bruno de Moura; Abreu, Sheila Rago Lemos; Paulino, Niraldo; Pastore, Gláucia Maria; Sato, Hélia Harumi; Theodoropoulos, Viviane Cristina Toreti; Tapia, Eulália Vargas; Park, Yong Kun; Caligiorne, Rachel Basques
    Background: Propolis has been used as a natural health product mainly due to the presence of polyphenols, flavonoids, phenolic aldehydes, amino acids, vitamins and others bioactive constituents. To this natural substance are attributed different biological and pharmacological properties which are influenced by its chemical composition and organoleptic properties. The aim of this work was to evaluate the physicochemical properties and parameters of green propolis collected during a period of six years (2008-2013) in the state of Minas Gerais, located at the southeastern region of Brazil. Methods: The methodology were in accordance with Brazilian legislation on the identity and quality standards of propolis. The evaluated parameters of hydroalcoholic from green propolis were total flavonoids, antioxidant activity - DPPH method, oxidation index, wax content, humidity and insoluble impurities. Results: Propolis samples collected in different seasons during the years 2008 to 2013 presented mean values of total flavonoids (3.4 ± 0.11 mg/g), antioxidant activity DPPH (4.76 ± 0.16 μg/mL), oxidation index (3, 4 ± 0.33 seconds) and wax (15.14 ± 0.78% m/m), which are in accordance with Brazilian legislation. Conclusion: Green propolis did not show abrupt seasonal changes during the six years of investigation, and may be considered as an adequate functional ingredient.