DEFAR - Departamento de Farmácia

URI permanente desta comunidadehttp://www.hml.repositorio.ufop.br/handle/123456789/530

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20191

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Autor: search.filters.author.Santos, Orlando David Henrique dosAssunto: search.filters.subject.Antibacterial

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    Development of propolis nanoemulsion with antioxidant and antimicrobial activity for use as a potential natural preservative.
    (2019) Seibert, Janaína Brandão; Silva, Jessica Paola Bautista; Amparo, Tatiane Roquete; Petit, Alicia; Pervier, Pauline; Almeida, Juliana Cristina dos Santos; Azevedo, Mariana Costa; Silveira, Benila Maria; Brandão, Geraldo Célio; Souza, Gustavo Henrique Bianco de; Teixeira, Luiz Fernando de Medeiros; Santos, Orlando David Henrique dos
    Propolis has demonstrated potential use as food preservative but it presents strong and unpleasant flavor that alters the sensory characteristics foods. A nanoemulsion was proposed to carry the Brazilian propolis extracts for use as natural food preservative. Antimicrobial and antioxidant activities and chemical constituents of the extracts were investigated. The latter were made by sequential extraction using different solvents (hexane, ethyl acetate and ethanol). Antimicrobial activity was evaluated by agar diffusion and microdilution methods and antioxidant activity by DPPH and ABTS assays. Extracts showed antibacterial and antioxidant activity, highlighting the ethanolic which contained artepillin-C, kaempferide, drupanin and p-coumaric acid as main compounds by LC-MS analysis. The nanoemulsion developed by phase inversion method was characterized and stable under thermal-stress and centrifugation conditions. Biological properties evaluated were effectively maintained by the formulation. It was concluded that the nanoemulsion can be used as a food preservative, preventing degradation and masking the propolis off-flavor.