DEFAR - Departamento de Farmácia
URI permanente desta comunidadehttp://www.hml.repositorio.ufop.br/handle/123456789/530
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Resultados da Pesquisa
Item Longitudinal study of plasma visfatin/nicotinamide phosphoribosyltransferase (nampt) levels in healthy pregnant women.(2023) Nunes, Priscila Rezeck; Cavalli, Ricardo de Carvalho; Belo, Vanessa de Almeida; Sandrim, Valeria Cristina; Luizon, Marcelo RizzattiVisfatin/nicotinamide phosphorybosil transferase (NAMPT) is a novel adipocytokine with potential roles in the patho- physiology of metabolic disorders, including gestational disorders. However, there is no clear interpretation regarding the circulating visfatin levels in a healthy pregnancy. Therefore, we conducted the frst longitudinal study of plasma visfatin levels that followed up healthy pregnant women until the third trimester, including the postpartum period (PPP). The study recruited healthy women with singleton pregnancy who were not using any drug (including tobacco and alcohol). We have excluded pregnant women who did not attend all scheduled exams and developed gestational diabetes or hypertension, obesity, preeclampsia, or any infections during pregnancy. Nine women were considered eligible and examined during all three trimesters of pregnancy and between 8 and 12 weeks postpartum (PPP). Visfatin/NAMPT concentrations were meas- ured in EDTA-plasma by ELISA. The mean age of pregnant women included was 22±5 years (54% primiparous), and the mean of gestational age at delivery was 40±1.2 weeks. Mean systolic and diastolic blood pressures were 90 and 70 mmHg, respectively. Mean values (± standard error mean) of visfatin concentrations (μg/L) during trimesters were 11.38±1.45 (frst, 11–14 weeks), 9.18±1.82 (second, 20–24 weeks), 18.67±2.65 (third, 34–36 weeks), and 10.12±1.49 in the PPP. The value of the third trimester was signifcantly higher than the second trimester, and signifcantly reduced in the PPP (p<0.05, ANOVA with Bonferroni’s multiple comparison tests). Visfatin/NAMPT levels are signifcantly lower in the PPP, suggesting that factors stimulating its production would be limited to pregnancy, thereby contributing to its potential application as a biomarker in pregnancy complications.Item NAMPT levels are inversely related to nitric oxide formation and positively related to soluble fms-like tyrosine kinase-1 levels in preeclampsia.(2019) Pereira, Daniela A.; Sandrim, Valeria Cristina; Palei, Ana Carolina Taveiros; Santos, José Eduardo Tanus dos; Belo, Vanessa de Almeida; Cavalli, Ricardo de Carvalho; Luizon, Marcelo RizzattiNAMPT is a biomarker for endothelial dysfunction, but its relationship with nitrite (marker of NO formation) and soluble fms-like tyrosine kinase-1 (sFLT-1) has not been previously evaluated in preeclampsia. Therefore, we measured plasma NAMPT and sFLT-1 levels using enzyme immunoassays and plasma nitrite concentrations using an ozone-based chemiluminescence assay. NAMPT was positively correlated to nitrite (r = 0.217; P = 0.034) and inversely related to sFLT-1 (r = −0.340; P = 0.029) in healthy pregnant women, but inversely related to nitrite (r = −0.259; P = 0.035) and positively correlated to sFLT-1 (r = 0.326; P = 0.007) in pre- eclamptic patients, suggesting that NAMPT inhibits NO formation and interacts with the antiangiogenic factor sFLT-1 in preeclampsia.