DEFAR - Departamento de Farmácia

URI permanente desta comunidadehttp://www.hml.repositorio.ufop.br/handle/123456789/530

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Autor: search.filters.author.Resende, Rodrigo RibeiroAssunto: search.filters.subject.Calcium channel

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    Expression and characterization of LTx2, a neurotoxin from Lasiodora sp. effecting on calcium channels.
    (2008) Dutra, Alexandre Augusto de Assis; Sousa, Lucas Oliveira; Resende, Rodrigo Ribeiro; Brandão, Rogélio Lopes; Kalapothakis, Evanguedes; Castro, Ieso de Miranda
    Here, we described the expression and characterization of the recombinant toxin LTx2, which was previously isolated from the venomous cDNA library of a Brazilian spider, Lasiodora sp. (Mygalomorphae, Theraphosidae). The recombinant toxin found in the soluble and insoluble fractions was purified by reverse phase high-performance liquid chromatography (HPLC). Ca2+ imaging analysis revealed that the recombinant LTx2 acts on calcium channels of BC3H1 cells, blocking L-type calcium channels.