DEFAR - Departamento de Farmácia
URI permanente desta comunidadehttp://www.hml.repositorio.ufop.br/handle/123456789/530
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Item High molecular weight adiponectin as a biomarker of hypertension in children and adolescents with obesity.(2023) Cunha, Warlley Rosa; Gaspar, Isabella Campos; Souza, Beatriz Cazarim de; Martins, Bárbara Dias Lana; Miranda, Josiane Aparecida de; Lanna, Carla Márcia Moreira; Santos, José Eduardo Tanus dos; Lacchini, Riccardo; Belo, Vanessa de AlmeidaLower HMW (high molecular weight) adiponectin levels are associated with obesity, insulin resistance, and metabolic syndrome in children and adolescents. However, data on HMW levels in pediatric population with hypertension are lacking. This study aimed to examine the association and predictive capacity of HMW levels, HMW/HOMA-IR, and HMW/APN ratio with hypertension in obese children and adolescents. The 299 pediatric subjects were grouped in obese hypertensive (OH), obese normotensive (ON), and normal weight normotensive (NN). Plasma concentrations of HMW were investigated by ELISA. ANOVA was used to compare study groups, and a binary logistic regression analysis was used to verify if HMW, HMW/HOMA-IR, HMW/APN, APN, APN/HOMA-IR, and HOMA-IR are associated to hypertension regardless obesity in children and adolescents. To compare the strength and performance of each biomarker to classify individuals with and without hypertension, the receiver-operating characteristic (ROC) curve, area under the curve (AUC), and Youden index (J) were evaluated. Both HMW plasma levels and the HMW/HOMA-IR ratio were significantly lower in the OH group when compared to the ON group (HMW: 2.00±1.33 μg/mL vs 2.48±1.48 μg/mL; HMW/HOMA-IR ratio: 0.87±0.95 vs 1.27±1.2; P<0.05) and NN weight groups (HMW: 2.00±1.33 μg/mL vs 4.02±1.99 μg/mL; HMW/HOMA-IR ratio: 0.87±0.95 vs 2.62±1.86; P<0.05). Hypertension was associated with lowest HMW (OR=4.50; 95% CI=1.41–15.84) and HMW/HOMA-IR (OR=12.13; 95% CI=2.51–92.93) regardless of obesity. However, HOMA-IR or the HMW/APN was not significant (P>0.05). In the ROC curve analyses, the HMW and HMW/HOM-IR were more sensitive to detect hypertension in children and adolescents with obesity. Conclusion: Low levels of HMW oligomer and HMW/HOM-IR are associated with hypertension in childhood obesity. Thus, these biomarkers could be clinically useful in identifying hypertension in childhood obesity.Item Menores níveis de adiponectina total associados com fatores de risco cardiometabólico em crianças e adolescentes.(2021) Barbosa, Carolina Abade; Rocha, Juliana Leal Maia da; Debossan, Lívia Costa; França, Mayara Valadares Lanza; Guedes, Renata Viana Hoffmann Monteiro; Veiga, Benedito de Oliveira; Lanna, Carla Márcia Moreira; Belo, Vanessa de AlmeidaObjetivo. Associar as concentrações dessa adipocina com fatores de risco cardiometabólicos (IMC, circunferência abdominal, HOMA-IR, TGL, HDL, colesterol e pressão arterial sistólica). Materiais e métodos. Crianças e adolescentes de 5 a 18 anos foram divididos em 3 grupos: 165 crianças/ adolescentes saudáveis, 114 crianças/adolescentes com obesidade e 74 crianças/adolescentes com obesidade/hipertensão. As dosagens de APN total foram determinadas no plasma EDTA pelo método ELISA sandwich. ANOVA foi usada para comparar os grupos definidos pelos quartis de APN total em relação aos fatores de risco cardiometabólicos. Resultados. As crianças e os adolescentes com obesidade/ hipertensão apresentaram menores níveis séricos de APN total (P<0,05). Menores níveis de APN total estão associados a fatores de risco metabólicos (IMC, circunferência abdominal, HOMA-IR, triglicerídeos, HDL, colesterol e pressão arterial sistólica) (P<0,05). Conclusão. Menores níveis de APN total são fatores associados à fatores de risco cardiometabólicos em crianças e adolescentes.