DEFAR - Departamento de Farmácia
URI permanente desta comunidadehttp://www.hml.repositorio.ufop.br/handle/123456789/530
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4 resultados
Resultados da Pesquisa
Item Synthesis of 4-octyl-2H-1,4-benzo-thiazin-3-ones.(2003) Guarda, Vera Lúcia de Miranda; Perrissin, Monique; Thomasson, François; Ximenes, Eulália Camelo Pessoa de Azevedo; Galdino, Suely Lins; Pitta, Ivan da Rocha; Luu-Duc, Cuong; Barbe, JacquesSynthesis, physical and analytical properties of 6-alkylacylamino-4-octyl-2H-1,4-benzo-thiazin-3-ones derivatives are described. These new compounds were prepared by acylation and/or alkylation of the amino group under phase transfer catalysis conditions. Acid hydrolysis of the alkylacylamino-2H-1,4-benzo-thiazin-3-ones afforded N-alkylamino-benzothiazin-3-ones. Some of these compounds were evaluated in vitro for possible bacteriostatic activity.Item Synthesis and microbiological activity of some 2H-1,4-benzothiazin-3-one derivatives.(2000) Guarda, Vera Lúcia de Miranda; Perrissin, Monique; Thomasson, François; Ximenes, Eulália Camelo Pessoa de Azevedo; Galdino, Suely Lins; Pitta, Ivan da Rocha; Luu-Duc, CuongThe synthesis and physicochemical properties of 4-butyl-2H-benzo[1,4]thiazin-3-one derivatives are described. These new compounds were synthesised by alkylation in 4-N position and acylation and/or alkylation of 6-NH2 by phase transfer catalysis. Acid hydrolysis of 6-alkylacylamino group yielded 6-alkylamino-4-butyl-2H-benzo[1,4]thiazin-3-ones. The antimicrobial in vitro activity was determined on five compounds.Item Crystal structure of 4-butyl-6-nitro-2H-1,4-benzothiazin-3-one, Z. Kristallogr.(2006) Simone, Carlos Alberto de; Guarda, Vera Lúcia de Miranda; Galdino, Suely Lins; Pitta, Ivan da RochaItem On the application of knoevenagel condensation for the synthesis of benzylidene benzothiazine compounds and structural study.(2006) Souza, Ana Maria Alves de; Guarda, Vera Lúcia de Miranda; Leite, Lucia Fernanda Cavalcanti da Costa; Barbosa Filho, José Maria; Lima, Maria do Carmo Alves de; Galdino, Suely Lins; Pitta, Ivan da RochaThe synthesis and physico-chemical properties of new 6-acetylamino or 6-benzoyl-amino 2-benzylidene-4-methyl-4Hbenzo[1,4]thiazin-3-ones and 6-benzoylamino or 6-nitro 2-benzylidene-4H-benzo[1,4]thiazin-3-ones are described. These benzylidene benzothiazine compounds were prepared by the Knoevenagel condensation with benzaldehydes. The configurations and conformations of benzylidene benzothiazine derivatives were optimised using the semi-empirical method AM1.