DEFAR - Departamento de Farmácia

URI permanente desta comunidadehttp://www.hml.repositorio.ufop.br/handle/123456789/530

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20181

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Autor: search.filters.author.Fuscaldi, Leonardo LimaAssunto: search.filters.subject.Biodistribution

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    Biodistribution of free and encapsulated 99mTc-fluconazole in an infection model induced by Candida albicans.
    (2018) Assis, Danielle Nogueira de; Araújo, Raquel Silva; Fuscaldi, Leonardo Lima; Diniz, Simone Odília Antunes Fernandes; Mosqueira, Vanessa Carla Furtado; Cardoso, Valbert Nascimento
    Candida spp is an etiologic agent of fungal infections in hospitals and resistance to treatment with antifungals has been extensively reported. Thus, it is very important to develop formulations that increase effectiveness with low toxicity. In this sense, nanocarriers have been investigated, once they modify drug biodistribution profile. Thus, this study aimed to evaluate the biodistribution of free and encapsulated 99mTc-fluconazole into nanocapsules (NCs) in an experimental immunosuppressed murine model of Candida albicans infection.