DEFAR - Departamento de Farmácia
URI permanente desta comunidadehttp://www.hml.repositorio.ufop.br/handle/123456789/530
Navegar
3 resultados
Resultados da Pesquisa
Item Nano-emulsions of the essential oil of Baccharis reticularia and its constituents as eco-friendly repellents against Tribolium castaneum.(2021) Lima, Luana A.; Sá, Paula S. Ferreira; Garcia Júnior, Manoel Daltro Nunes; Pereira, Vera Lúcia P.; Carvalho, José Carlos Tavares; Rocha, Leandro; Fernandes, Caio Pinho; Souto, Raimundo Nonato Picanço; Araújo, Raquel Silva; Botas, Gisele da Silva; Cruz, Rodrigo Alves SoaresNanoproducts based on natural products have been studied as ecologically and economically sustainable alter- natives for crop pest control. Baccharis reticularia DC. is a shrub endemic to Brazil, which leaves are traditionally used in aromatic medicinal baths. This study aims to evaluate the repellent activities of nano-emulsions con- taining the B. reticularia phytochemically characterized essential oil and some of its monoterpene constituents (limonene, α-pinene, and β-pinene) against Tribolium castaneum (Herbst). Essential oil was obtained by hydro- distillation of fresh leaves and stems and yielded 0.28 % (w/w). The main constituents of the essential oil were: limonene (14.6 %), β-myrcene (12.6 %), and bicyclogermacrene (12.5 %). The required hydrophile-lipophile balance (rHLB) of the nano-emulsions were: 13 (α-pinene) and 15 (essential oil, limonene, and β-pinene). All nano-emulsions showed mean droplet sizes bellow 200 nm and remain stable, at least, for 28 days (limonene), 90 days (β-pinene), or 150 days (essential oil and α-pinene). All nano-emulsions exhibited repellent activity against T. castaneum at 8.8 μg/cm2 . Limonene and α-pinene were the most active nano-emulsions, showing significant repellent action at 1.1 μg/cm2 , which indicates that these compounds contribute to the repellent action of the essential oil of B. reticularia. The present study opens perspectives for the utilization of B. reticularia essential oil and its constituents as raw material of new promising nanopesticides produced using a low energy, solvent-free and ecofriendly method. Thus, this work contributes significantly to the search for new ecologically correct strategies for the control of T. castaneum.Item Double-blind clinical study of a multivitamin and polymineral complex associated with Panax ginseng extract (Gerovital®).(2010) Perazzo, Fábio Ferreira; Fonseca, Fernando L. A.; Souza, Gustavo Henrique Bianco de; Maistro, Edson Luis; Rodrigues, Marcelo; Carvalho, José Carlos TavaresThe present study aimed to evaluate the efficacy of a multivitamin and poly minerals supplemented with Panax ginseng extract (Gerovital®) on patients suffering from common physical or mental stress. The study design was controlled, parallel and double blind. Patients were randomly divided in two groups and underwent a thorough clinical and laboratory examination. Group A received placebo capsules and group B received Gerovital® capsules. In both cases, two capsules were taken daily during meals for eight weeks. Mood as well as physical activity were evaluated through a questionnaire assessing quality of life. From the 126 patients enrolled, 12 patients (8 in group A and 4 in group B) were excluded due to voluntary withdrawal, 55 patients completed the study in group A and 59 in group B. The treatment with Gerovital® significantly increased the quality of life when compared to placebo. After 15 days of study no difference between groups was observed. However, at 30th, 45th and 60th day, group B showed a statistically significant increase in average score from 30.05 to 41.96, 47.01 and finally 50.81 points. No increase in body weight was detected in either group. No difference in blood pressure or heart rate was also observed between treatments. The present study has shown that the daily use of Gerovital® over a 2-month period can be effective in improving quality of life in patients suffering from physical and mental stress among individuals of different ages, ranging from adults to elderly. Moreover, its use has been associated to a lower incidence of flu-like seasonal respiratory illnesses. Finally, the incidence of undesired effects was similar to placebo.Item Phase II clinical study of an association for the treatment of interstitial cystitis (Cystex®).(2012) Souza, Gustavo Henrique Bianco de; Maistro, Edson Luis; Rodrigues, Marcelo; Carvalho, José Carlos Tavares; Fonseca, Fernando L. A.; Lopes, Andrey Pereira; Perazzo, Fábio FerreiraPainful bladder syndrome associated with interstitial cystitis (PBS/IC) is a clinical condition characterized pelvic pain, urinary urgency, and urinary frequency. In this study, 22 patients were assigned to make two visits over a three weeks period. The patients were randomly, double-blinded assigned in two groups. The first group received Cystex® capsules. The second group received placebo capsules. Two capsules were taken three times a day away from meals. The change from baseline in the O’Leary-Sant IC symptom and problem index was the primary outcome parameter. Changes in functional bladder capacity and intensity of pain and urgency have been chosen as secondary outcome parameters. Mood as well as physical and sexual activity were rated by 10 questions on a scale 0 to 6. The ratings were analyzed and the average for each patient in both groups Cystex® and placebo was determined as the quality of life index. For the primary outcome there was a statistically significant difference between the groups. Mean symptom score-sum decreased from 28.4 to 20.5 in the Cystex® group compared with 29.5 to 26.8 in the placebo group (p<0.05). For the secondary end points, pain and urgency intensity improved statistically significantly in the Cystex® group compared with the placebo group (p<0.05). The frequency and functional bladder capacity improved to greater degree in the Cystex® group. The differences were statistically significant for comparison of frequency (p<0.05) and not for functional bladder capacity (p>0.05). In our study, Cystex® enhanced quality of life over the placebo showing a statistically significant. This trial have shown that the efficacy and safety of therapy with Cystex® in the treatment of interstitial cystitis and is an alternative for patients suffering from this pathology. Therefore, it can be concluded that the composition of Cystex®, increased the quality of life in treated patients.