DEFAR - Departamento de Farmácia

URI permanente desta comunidadehttp://www.hml.repositorio.ufop.br/handle/123456789/530

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2013 - 20172

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Autor: search.filters.author.Cabral, Vivette Appolinário Rodrigues

Resultados da Pesquisa

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    Antibacterial activity of extract and fractions from branches of Protium spruceanum and cytotoxicity on fibroblasts.
    (2017) Amparo, Tatiane Roquete; Rodrigues, Ivanildes Vasconcelos; Seibert, Janaína Brandão; Souza, Rafaella Hilda Zaniti; Oliveira, Amanda Ribeiro de; Cabral, Vivette Appolinário Rodrigues; Vieira, Paula Melo de Abreu; Brandão, Geraldo Célio; Okuma, Adriana Akemi; Vieira Filho, Sidney Augusto; Teixeira, Luiz Fernando de Medeiros; Souza, Gustavo Henrique Bianco de
    The crude ethanol extract (CEE) and fractions from branches of Protium spruceanum were subjected to antibacterial and cytotoxicity assays. Compounds of the most active fraction were identified by GC-MS and LC-MS. CEE was active against 19 bacteria and the ethyl acetate fraction (EAF) showed the lowest minimum bactericidal concentration (MBC 0.3–80.0 mg/mL). Through time-kill assay was observed that EAF induced rapid bactericidal effect against Staphylococcus saprophyticus. The cytotoxicity tests against L929 fibroblasts showed great potential of EAF on the treatment of infections caused by five bacteria (MBC < IC50). The results provide in vitro scientific support to the possible application of branches of P. spruceanum as antimicrobial agent that may contribute for treatment of infections.
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    Antiedematogenic and antinociceptive effects of leaves extracts from Protium spruceanum Benth.
    (2013) Rodrigues, Ivanildes Vasconcelos; Souza, Juliana Neves de Paula; Silva, Ana Cláudia G.; Chibli, Lucas Apolinário; Cabral, Vivette Appolinário Rodrigues; Vieira Filho, Sidney Augusto; Perazzo, Fábio Ferreira; Guimarães, Andrea Grabe; Souza, Gustavo Henrique Bianco de
    Ethnopharmacological relevance: In traditional medicine, gums and oil-resins from Protium species have been used for many diseases, however, there are no reports of studies of Protium spruceanum’ leaves. Materials and methods: The antiedematogenic and antinociceptive effects of crude ethanol extract (EEB) from leaves of P. spruceanum and its fractions were evaluated in biological models. The fractions were obtained with hexane (FHEX) and methanol (FMEOH). Rat paw edema induced by carrageenan, writhing test, formalin test, hot plate test and the toxicity of EEB were performed. Results: Phytochemical analysis has shown the presence of a and b-amyrins as major constituents of FHEX. Promising results of anti-inflammatory and antinociceptive activity were found for EEB, FHEX and FMEOH. Also were observed the EEB at 6000 mg/kg showed no toxicity. Conclusions: One might suggest that the activities of FHEX are due to the presence of a and b-amyrins and contributes to the biological activities of EEB.