DEFAR - Departamento de Farmácia

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Recent progress in micro and nano-encapsulation of bioactive derivatives of the Brazilian genus Pterodon.
(2021) Lemos, Janaina de Alcantara; Oliveira, Anna Eliza M. F. M.; Araújo, Raquel Silva; Townsend, Danyelle M.; Ferreira, Lucas Antônio Miranda; Barros, André Luís Branco de
In the last few decades, utilization of medicinal plants by the pharmaceutical industry has led to the identifi- cation of many new bioactive compounds. The genus Pterodon, native of the Brazilian Flora, is known for the therapeutic properties attributed to its species, which are widely used in popular medicine for their anti- inflammatory, anti-rheumatic, tonic, and depurative properties. The intrinsic low water solubility of the plant derivatives from the genus, including diterpenes with vouacapane skeletons that are partially associated with the pharmacological activities, impairs the bioavailability of these bioactive compounds. Recent studies have aimed to encapsulate Pterodon products to improve their water solubility, achieve stability, increase their efficacy, and allow clinical applications. The purpose of this paper is to review recent research on the use of nanotechnology for the development of new products from plant derivatives of the Pterodon genus in different types of micro- and nanocarriers. Therapeutic properties of their different products are also presented. Finally, an update about the current and future applications of encapsulated formulations is provided.