DEFAR - Departamento de Farmácia

URI permanente desta comunidadehttp://www.hml.repositorio.ufop.br/handle/123456789/530

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2017 - 201912020 - 20231

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Autor: search.filters.author.Aquino, Sergio Francisco de

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    Water treatment technologies for removing priority pesticides.
    (2023) Brovini, Emília Marques; Moreira, Fernanda Deister; Martucci, Maria Elvira Poleti; Aquino, Sergio Francisco de
    The development of technologies to remove pesticides from environmental matrices is an important issue as they may be toxic to the environment and human health. The objective of this review is to understand the treatability of five selected pesticides including the main treatment processes and conditions employed worldwide to remove them. Despite its widespread use in water treatment plants (WTP), conventional technologies alone were only tested for atrazine and resulted in low average removal (up to 50 %). Several studies using advanced oxidation processes have been successful for atrazine, but few experiments have been performed under practical condi- tions. Regarding reported efficiencies, 80 % of atrazine was degraded when conventional treatment was followed by ozonation using aluminum sulfate and magnafloc LT 22 as coagulants and ozone as disinfectant. For acephate and methamidophos, the use of titanium dioxide was the best treatment, leading to 87.7 % to 100 % removal in laboratory-scale experiments. Anodic Fenton treatment and a combination of Fenton and ultrasound exhibited high (99 and 100 %, respectively) carbofuran removal efficiencies. In terms of time and conditions tested, the membrane anodic Fenton treatment was the best one, but large-scale application needs to be further evaluated. In general, advanced oxidation processes are good complementary technologies. However, understanding the fate and toxicity of the transformation by-products is crucial, as well as its applicability (economic and envi- ronmental sustainability) on a large scale.
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    High resolution mass spectrometry elucidation of captopril´s ozonation and chlorination by-products.
    (2017) Quintão, Frederico Jehár Oliveira; Brandão, Geraldo Célio; Silva, Silvana de Queiroz; Aquino, Sergio Francisco de; Afonso, Robson José de Cássia Franco
    The article evaluated the degradation of the captopril in aqueous solution after ozonation and chlorination. The process was continuously monitored focusing on the identification, mass spectrometry and elucidation of its by-products by applying direct infusion and high performance liquid chromatography, electrospray ionization high resolution mass spectrometry, in the negative ion mode. The cytotoxicity of its by-products solutions were evaluated with 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. It was observed through that after 30 min of ozonation and chlorination, there was complete oxidation of captopril, i .e ., 100% removal efficiency. At these conditions, the rate of mineralization, by total organic carbon, was only 7.63% for ozonation and 6.40% for chlorination, evidencing the formation of degradation by-products. Ten captopril by-products were identified and their respective chemical structures elucidations are proposed. The treated samples and their by-products were nontoxic to HepG2 cells by MTT assay.