DEFAR - Artigos publicados em periódicos

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Biological activities of extracts from Padina Boergesenii and Sargassum Stenophyllum, seaweeds naturally found in Baia de Todos os Santos, Brazil.
(2015) Oliveira, Naiara Maia; Meira, Carla Larissa Costa; Aguiar, Rosane Moura; Oliveira, Djalma Menezes de; Moura, Carlos Wallace do Nascimento; Vieira Filho, Sidney Augusto
Objective: Here we present the results of the biological potential as antioxidant, anti-cancer and leishmaniscidal from extracts of Padina boergesenii Allender & Kraft and of Sargassum stenophyllum Martius, seaweed species commonly found in bay of the Brazilian Atlantic coast named Baía de Todos os Santos, state Bahia. In addition, we reported on the chemical composition of extractive fractions from these algae. Methods: Phytochemicals prospecting methods such as thin layer chromatography (TLC) and spectrometry in the UV/Vis region were used to identify the chemical class of constituents from these algae extracts. Antioxidant potential of the fractions was evaluated using the α,α-diphenyl-β-picrylhydrazyl (DPPH) free radical scavenging method. The cytotoxic potential of seaweed extracts against the human breast cancer (MFC-7) cell lines was evaluated using the sulforhodamine B (SRB) colorimetric assay. The leishmanicidal effect of algae extracts against promastigotes of Leishmania amazonenses Laison & Shaw 1972 was evaluated using amphotericin B (AMB) as positive control. Results: Were detected flavonoids, steroids, carotenoids, anthocyanins and phenolic compounds from algae extracts in hexane, chloroform and n-butanol. Overall, extractive fractions showed moderate antioxidant activities in comparison with quecertin, butylated hydroxytoluene and gallic acid. Fractions from P. boergesenii and chloroform fraction of S. stenophyllum presented significant activity against MCF-7 cells by inhibiting the cells grown among 55.0 to 66.0 %. These results were closely similar to inhibition reached by colchicine (67.0 %) used as positive control. No antileishmanial significant effect was observed for P. boergesenii and S. stenophyllum extracts at the tested conditions. Conclusion: The results indicated a promissory pharmacologic potential for the P. boergesenii and S. stenophyllum extracts, Which open perspectives to the isolation of their active constituents.
Photoprotective property and cytotoxicity of polar extracts of three species of Maytenus native to the Southwest of Bahia.
(2020) Pereira, Rosângela dos Santos; Aguiar, Rosane Moura; Lemos, Gisele da Silveira; Vieira Filho, Sidney Augusto; Oliveira, Djalma Menezes de
Maytenus acanthophylla, M. rigida and M. truncata (Celastraceae) are used in the traditional medicine of Chapada Diamantina and Southwest Bahia, Brazil. The infusion and decocto of its leaves are used in the treatment of inflammation and gastric disorders. In this context, it is important to identify chemical and biological properties that reinforce this traditional use. The objective of this study was to determine the total phenolic and flavonoid content by the Folin-Ciocalteau method, the photoprotective property by in vitro spectrophotometric method and the acute toxicity by the mortality index of Artemia salina, of polar extracts of these three Maytenus species. It was observed that the species have similar levels of total phenolic and flavonoid. The presence of compounds containing chromophore groups, which absorb radiation in the UV region between 290 and 320 nm, gives the extracts promising sun protection factors. In the tests with A. salina, the median lethal concentration values were high (≥1000.0 μg/mL) indicating the low toxicity of these extracts. The results contribute to the knowledge of the polar extracts of the three Maytenus species of the Southwest of Bahia, to the validation of the therapeutic properties of these plants and opens perspectives of new studies of photoprotection.