Navegando por Autor "Zani, Carlos Leomar"

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Estudo fitoquímico do decocto das folhas de maytenus truncata reissek e avaliação das atividades antinociceptiva, antiedematogênica e antiulcerogênica de extratos do decocto.
(2007) Fonseca, Ana Paula Nascentes de Deus; Silva, Grácia Divina de Fátima; Carvalho, Juliana de Jesus; Meléndez Salazar, Gloria Del Carmen; Duarte, Lucienir Pains; Silva, Renata Pamplona; Jorge, Rodrigo Martinez; Tagliati, Carlos Alberto; Zani, Carlos Leomar; Alves, Tânia Maria de Almeida; Peres, Valdir; Vieira Filho, Sidney Augusto
The present paper describes the phytochemical investigation and biological activities of the chloroform, ethyl acetate and methanol extracts of leaf decocts of M. truncata Reiss (Celastraceae). Our studies afforded two flavonoid glycosides, quercetin-3-Orhamnopyranosyl- O-glucopyranosyl-O-rhamnopyranosyl-O-galactopyranoside (1) and kampferol-3-O-rhamnopyranosyl-Oglucopyranosyl- O-rhamnopyranosyl-O-galactopyranoside (2) from the methanolic extract and dulcitol (3) from the ethyl acetate extract. Ethyl acetate and methanol extracts exhibited considerable antiulcerogenic and analgesic activities. The results of the phytochemical studies suggest that the healing activity of methanol extracts can be related to the presence of glycosyl flavonoids.
In vitro and in vivo experimental models for drug screening and development for Chagas disease.
(2010) Romanha, Alvaro José; Castro, Solange Lisboa de; Soeiro, Maria de Nazaré Correia; Vieira, Joseli Lannes; Ribeiro, Isabela; Silva, André Talvani Pedrosa da; Bourdin, Bernadette; Blum, Bethania; Olivieri, Bianca; Zani, Carlos Leomar; Spadafora, Carmenza; Chiari, Egler; Chatelain, Eric; Chaves, Gabriela; Calzada, José Eduardo; Bustamante, Juan Manuel; Freitas Junior, Lucio Holanda Godim de; Romero, Luz I.; Bahia, Maria Terezinha; Lotrowska, Michel; Soares, Milena Botelho Pereira; Andrade, Sonia Gumes; Lotrowska, Tanya; Degrave, Wim; Andrade, Zilton de Araújo
Chagas disease, a neglected illness, affects nearly 12-14 million people in endemic areas of Latin America. Al¬though the occurrence of acute cases sharply has declined due to Southern Cone Initiative efforts to control vector transmission, there still remain serious challenges, including the maintenance of sustainable public policies for Chagas disease control and the urgent need for better drugs to treat chagasic patients. Since the introduction of benznidazole and nifurtimox approximately 40 years ago, many natural and synthetic compounds have been as¬sayed against Trypanosoma cruzi, yet only a few compounds have advanced to clinical trials. This reflects, at least in part, the lack of consensus regarding appropriate in vitro and in vivo screening protocols as well as the lack of biomarkers for treating parasitaemia. The development of more effective drugs requires (i) the identification and validation of parasite targets, (ii) compounds to be screened against the targets or the whole parasite and (iii) a panel of minimum standardised procedures to advance leading compounds to clinical trials. This third aim was the topic of the workshop entitled Experimental Models in Drug Screening and Development for Chagas Disease, held in Rio de Janeiro, Brazil, on the 25th and 26th of November 2008 by the Fiocruz Program for Research and Technological Development on Chagas Disease and Drugs for Neglected Diseases Initiative. During the meeting, the minimum steps, requirements and decision gates for the determination of the efficacy of novel drugs for T. cruzi control were evaluated by interdisciplinary experts and an in vitro and in vivo flowchart was designed to serve as a general and standardised protocol for screening potential drugs for the treatment of Chagas disease.