Navegando por Autor "Souza, Laura Alves Cota e"
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Item Climacteric symptoms and quality of life in yoga practitioners.(2020) Souza, Laura Alves Cota e; Reis, Ilka Afonso; Lima, Angélica AlvesBackground: Yoga is among the most commonly studied complementary therapies for managing climacteric symptoms. However, it is unclear whether yoga practices in premenopause can affect the occurrence of symptoms when women reach menopause. Objective: To assess climacteric symptoms and quality of life in regular yoga practitioners and to determine whether yoga practices before menopause may avoid or mitigate climacteric-related symptoms. Design: This study of 108 women between 40 and 65 years old included 28 women who started to practice yoga in premenopause and had already practiced for at least five years, and as controls 30 physical activity practitioners (PA) who had practiced for at least five years, and 50 sedentary women. Main outcome measures: Climacteric symptoms were evaluated with the Kupperman Menopausal Index (KMI) and the Women’s Health Questionnaire (WHQ). Moreover, we measured the quality of life with the WHQ. Results: The KMI showed that 39.3% of yoga practitioners had no menopausal symptoms, and none reported severe symptoms. The WHQ indicated a few symptoms and a good quality of life for yoga practitioners (3.56; 3.353.80). In addition, we found that the yoga group had significantly less moderate and severe symptoms (p = 0.002) compared with the sedentary group. We also observed that yoga practitioners had less vasomotor symptoms and memory/concentration disorders than PA practitioners (p = 0.010 and p = 0.047) and sedentary women (p = 0.001 and p = 0.001) and also used fewer drugs than the PA (p < 0.001) and the sedentary groups (p = 0.001). Conclusions: Yoga practitioners who started to practice in premenopause had satisfactory results on the frequency and intensity of climacteric symptoms and quality of life. Although further research is required to support our findings, we conclude that yoga practice may represent an efficient non-pharmacological approach to manage and prevent climacteric symptoms.Item Correlation of serum anti‑Mullerian hormone with hormonal and environmental parameters in Brazilian climacteric women.(2023) Gouvea, Thiago Magalhães; Souza, Laura Alves Cota e; Lima, Angélica AlvesThis study aimed to identify the correlation among anti-Mullerian Hormone serum levels and 25-OHD, obesity, metabolic syndrome (MetS), and sexual hormones in climacteric women classifed according to stages of reproductive aging (SRA). A cross-sectional study was conducted with a total of 177 Brazilian climacteric women between 40 and 64 years old. Concentrations of AMH were measured using the Access 2 Immunoassay System. A multiple linear regression analysis was used to identify the relationship among AMH, 25-OH-D, obesity, MetS, sexual hormones, sociodemographic and lifestyle factors. AMH levels decreased with increased age (B= − 0.059; p< 0.001), and reproductive aging (B= − 0.483; p< 0.001). Obesity indicators, lifestyle characters, 25-OH-D levels and MetS were not signifcantly associated with AMH serum concentration. Negative correlation was found for FSH (B= − 0.009; p< 0.001) and LH (B= − 0.006; p= 0.004); positive correlation for E2 (B= 0.001; p= 0.011), DHEAS (B= 0.003; p< 0.001) and SHBG (B= 0.003; p= 0.005). In the model adjusted for SRA, FSH levels (p< 0.001) and DHEAS (p= 0.014) were associated with AMH. Although, with the adjustment for age, only FSH remained with a signifcant association (p= 0.001). Of the other analytes, none was associated with AMH, regardless of the model ft. Our fndings confrm that serum AMH level decreased with age and FSH levels, but there is no correlation between AMH with obesity, 25-OH-D, MetS or other sexual hormones in Brazilian climacteric women.Item Efeito da prática de yoga sobre sintomas, variáveis antropométricas, laboratoriais e clinicas de mulheres no climatério.(2022) Souza, Laura Alves Cota e; Lima, Angélica Alves; Lima, Angélica Alves; Monteiro, Henrique Luiz; Campos, Helena Hachul de; Barra, Alexandre de Almeida; Isoldi, Mauro CésarO climatério é uma fase da vida feminina caracterizada pela ocorrência de sintomas e alterações metabólicas, que acontecem principalmente devido ao declínio dos níveis de estrogênio. Alguns estudos já mostraram que a prática de Yoga pode melhorar a qualidade de vida das mulheres no climatério. Contudo, ainda faltam evidências acerca dos efeitos do Yoga sobre as alterações metabólicas que ocorrem durante a transição menopausal e pós-menopausa, bem como sobre o momento mais apropriado para o início das práticas e o tempo necessário para que os benefícios sejam observados. Assim, o objetivo deste trabalho foi avaliar o efeito da prática regular de Yoga sobre sintomas, parâmetros antropométricos, laboratoriais e clínicos de mulheres no climatério. Para tal, foram selecionadas 373 mulheres de 40 a 65 anos, as quais foram distribuídas em dois grupos: Yoga (n=187) e Controle (n=186). Todas as participantes foram avaliadas antes do início do estudo (AI) e após seis, doze e vinte e quatro meses (AF). As análises incluiram (a) entrevista para levantamento dos sintomas, características sociodemográficas e comportamentais; (b) medidas antropométricas; (c) testes laboratoriais: perfil lipídico, glicemia e hormônios; (d) avaliação de síndrome metabólica e do risco cardiovascular. Os resultados mostraram redução significativa da intensidade dos sintomas climatéricos após 6 (p<0,001), 12 (p=0,008) e 24 meses (p=0,027) de práticas de Yoga. Em relação aos parâmetros antropométricos avaliados, foi observada diminuição significativa do índice de massa corporal (IMC) após 24 meses de práticas de Yoga (-2,2kg/m2 ; p=0,008) e da porcentagem de gordura corporal (GC) após 6 (-0,9%; p=0,036) e 24 meses (-4,3%; p=0,008). Na análise dos parâmetros laboratoriais, foi observado aumento do HDLc (9,6 mg/dL; p=0,012) e do índice QUICKI (0,03; p=0,046) após 24 meses de práticas de Yoga, além de redução da glicemia de jejum (GJ) (-9,1 mg/dL; p=0,024) e do colesterol não-HDLc (-23,4 mg/dL; p=0,018) após este mesmo período. A comparação intergrupo após os diferentes períodos de acompanhamento (AF) também mostrou que, para a maioria das variáveis avaliadas, as praticantes de Yoga apresentaram resultados significativamente melhores em comparação ao grupo Controle. Desta forma, os achados deste trabalho mostram que a prática regular de Yoga teve efeito benéfico sobre sintomas, parâmetros antropométricos, laboratoriais e clínicos, podendo representar uma abordagem não farmacológica atrativa para mulheres no climatério.Item The correlation of the fecal microbiome with the biochemical profle during menopause : a Brazilian cohort study.(2022) Silva, Thayane Christine Alves da; Gonçalves, Jennefer Aparecida dos Santos; Souza, Laura Alves Cota e; Lima, Angélica Alves; Cota, Renata Guerra de SáBackground: Hormonal, biochemical, and metabolic changes after menopause may alter the quality of life of women, leading to vasomotor, psychological, and genitourinary symptoms, and changes in their gut microbiota, which regulates estrogen levels through the estroboloma. Fecal samples were used to investigate the changes in the gut microbiota during aging and hormonal changes in women. A balanced gut microbiota has been associated with health or disease conditions and remains poorly understood after menopause. This study identifed the fecal micro‑ biota, and their association with biochemical and hormonal parameters of a cohort of women in the climacteric in the city of Ouro Preto—MG, Brazil. Methods: A total of 102 women aged 40 to 65 years old were recruited and distributed into three groups accord‑ ing to the STRAW criteria for reproductive stage: reproductive (n=18), premenopausal (n=26), and postmenopausal (n=58). Blood samples were collected to measure their serum biochemical and hormone levels, and the participants answered a questionnaire. The gut microbiota was analyzed from fecal samples by qPCR using the genera Bifdobacterium, Bacteroides, Lactobacillus, and Clostridium. Results: The following parameters showed diferences among the groups: total cholesterol, triglycerides, VLDL, ApoB, urea, calcium, uric acid, and alkaline phosphatase (p<0.05). qPCR revealed the genus Clostridium to be the most abundant in all three groups. In the reproductive age group, the signifcant correlations were: Bacteroides with glucose (r= -0.573 p=0.0129), and SDHEA (r= -0.583 p=0.0111). For the premenopausal group, they were: Bifdobacteria with total cholesterol (r=0.396 p=0.0451), LDL (r=0.393 p=0.0468), ApoB (r=0.411 p=0.0368); Lactobacillus and cal‑ cium (r=0.443 p=0.0232), ALP (r=0.543 p=0.0041), LPa (r=-0.442 p=0.02336); and Bacteroides and urea (r=-0.461 p=0.0176). In the postmenopausal group, they were Bifdobacterium and ALP (r=-0.315 p=0.0159), Lactobacillus and urea (r=-0.276 p=0.0356), and Clostridium and beta estradiol (r=-0.355 p=0.0062). Conclusion: In conclusion, the hormonal and metabolic changes during menopause in the population studied were accompanied by a signifcant change in the fecal microbiota, especially of the genus Clostridium.Item Uric acid level in climacteric women and its association with clinical and metabolic parameters.(2023) Souza, Laura Alves Cota e; D’Angelo, Georgia Carvalho de Oliveira; Silva, Glenda Nicioli da; Lima, Angélica AlvesClimacteric women often experience unfavorable metabolic changes. Consequently, identifying markers that may contribute to such undesirable changes is imperative. This study aimed to evaluate serum uric acid (UA) concentration and its association with metabolic and clinical parameters in climacteric women. We selected 672 women between 40 and 65 years and performed interviews, biochemical analyses, blood pressure, and anthropometric measurements. UA levels were determined using the enzymatic-colorimetric method. We compared variables according to the quartiles of UA using the Kruskal–Wallis test. The mean UA level was 4.9 ± 1.5 mg/dl, ranging from 2.0 to 11.6 mg/dl. We found that UA levels greater than 4.8 mg/dl were associated with adverse metabolic parameters in climacteric women. For all anthropometric and biochemical variables, we observed signifcantly better results in women who had lower UA levels (p< 0.05). Similarly, we observed a signifcant increase in blood pressure, frequency of metabolic syndrome, and cardiovascular risk as UA levels increased (p< 0.05). Our fndings showed that climacteric women with high levels of UA were more likely to have adverse metabolic and clinical parameters than those with lower UA levels. Further studies may determine the causal relationship between UA and metabolic changes in climacteric women.