Navegando por Autor "Sousa, Luciana Pereira de"
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Item Dynamics and immunomodulation of cognitive deficits and behavioral changes in non-severe experimental malaria.(2022) Gonçalves, Pamela Rosa; Sousa, Luciana Pereira de; Maia, Aline Barbosa; Gomes, Flávia Lima Ribeiro; Gress, Caroline Cristhiani Tavares de Lima; Werneck, Guilherme Loureiro; Souza, Diogo Onofre; Almeida, Roberto Farina de; Ribeiro, Cláudio Tadeu DanielData recently reported by our group indicate that stimulation with a pool of immunogens capable of eliciting type 2 immune responses can restore the cognitive and behavioral dysfunctions recorded after a single episode of nonsevere rodent malaria caused by Plasmodium berghei ANKA. Here we explored the hypothesis that isolated immunization with one of the type 2 immune response-inducing immunogens, the human diphtheria-tetanus (dT) vaccine, may revert damages associated with malaria. To investigate this possibility, we studied the dynamics of cognitive deficits and anxiety-like phenotype following non-severe experimental malaria and evaluated the effects of immunization with both dT and of a pool of type 2 immune stimuli in reversing these impairments. Locomotor activity and long-term memory deficits were assessed through the open field test (OFT) and novel object recognition task (NORT), while the anxiety-like phenotype was assessed by OFT and light/dark task (LDT). Our results indicate that poor performance in cognitive-behavioral tests can be detected as early as the 12th day after the end of antimalarial treatment with chloroquine and may persist for up to 155 days post infection. The single immunization strategy with the human dT vaccine showed promise in reversal of long-term memory deficits in NORT, and anxiety-like behavior in OFT and LDT.Item Immune system challenge improves recognition memory and reverses malaria‐induced cognitive impairment in mice.(2021) Sousa, Luciana Pereira de; Gomes, Flávia Lima Ribeiro; Almeida, Roberto Farina de; Souza, Tadeu Mello e; Werneck, Guilherme Loureiro; Souza, Diogo Onofre; Ribeiro, Cláudio Tadeu DanielThe immune system plays a role in the maintenance of healthy neurocognitive function. Diferent patterns of immune response triggered by distinct stimuli may afect nervous functions through regulatory or deregulatory signals, depending on the properties of the exogenous immunogens. Here, we investigate the efect of immune stimulation on cognitive-behavioural parameters in healthy mice and its impact on cognitive sequelae resulting from non-severe experimental malaria. We show that immune modulation induced by a specifc combination of immune stimuli that induce a type 2 immune response can enhance long-term recognition memory in healthy adult mice subjected to novel object recognition task (NORT) and reverse a lack of recognition ability in NORT and anxiety-like behaviour in a light/dark task that result from a single episode of mild Plasmodium berghei ANKA malaria. Our fndings suggest a potential use of immunogens for boosting and recovering recognition memory that may be impaired by chronic and infectious diseases and by the efects of ageing.