Navegando por Autor "Sinisterra, Ruben Dario"
Agora exibindo 1 - 7 de 7
Resultados por página
Opções de Ordenação
Item Buscas de informações tecnológicas com base em dados de patentes : estudo de caso dos líquidos iônicos no Brasil.(2015) Speziali, Marcelo Gomes; Sinisterra, Ruben DarioThis study describes the application of the Art of Scientific and Technological Search to strategically analyze areas of technological and industrial development. Application of scientific search strategies such as the creation of Patent Landscape has been shown to be useful for writing research projects, earning grants, publishing papers, drafting patent applications, and analyzing the market and economic potentials of a previous determined subject. The Patent Landscape regards a simplified analysis of technologies concerning ionic liquids patents applied in Brazil and published by Instituto Nacional da Propriedade Industrial (INPI). A total of 93 patent applications using the keywords “ionic liquids” were found in the INPI database. Among these, 75% were nonresident applications and 25% were Brazilian resident applications. Interestingly, BASF, Chevron Industries, and the Universidade Federal do Rio Grande do Sul (UFRGS) were discovered as higher patent applicant assignees. Differences in the patent application areas were also observed between these applicants, with new solvents and petrochemical applications as the areas of focus for the industrial applications (BASF and Chevron Industries), and energy production, catalysis, and chemical reaction media as the focus for the university applications.Item Magnesium (Mg2+), Strontium (Sr2+), and Zinc (Zn2+) Co‑substituted bone cements based on nano‑hydroxyapatite/ monetite for bone regeneration.(2022) Dias, Alexa Magalhães; Canhas, Isabela do Nascimento; Bruziquesi, Carlos Giovani Oliveira; Speziali, Marcelo Gomes; Sinisterra, Ruben Dario; Cortés Segura, María EsperanzaNew bone cement type that combines Sr2+/Mg2+or Sr2+/Zn2+co-substituted nano-hydroxyapatite (n-HAs) with calcium phosphate dibasic and chitosan/gelatin polymers was developed to increase adhesion and cellular response. The cements were physicochemically described and tested in vitro using cell cultures. All cements exhibited quite hydrophilic and had high washout resistance. Cement releases Ca2+, Mg2+, Sr2+, and Zn2+in concentrations that are suitable for osteoblast proliferation and development. All of the cements stimulated cell proliferation in fbroblasts, endothelial cells, and osteoblasts, were non-cytotoxic, and produced apatite. Cements containing co-substituted n-HAs had excellent cytocompatibility, which improved osteoblast adhesion and cell proliferation. These cements had osteoinductive potential, stimulating extracellular matrix (ECM) mineralization and diferentiation of MC3T3-E1 cells by increasing ALP and NO production. The ions Ca2+, Mg2+, Zn2+, and Sr2+appear to cooperate in promoting osteoblast function. The C3 cement (HA-SrMg5%), which was made up of n-HA co-substituted with 5 mol% Sr and 5 mol% Mg, showed exceptional osteoinductive capacity in terms of bone regeneration, indicating that this new bone cement could be a promising material for bone replacement.Item Oral formulation of Angiotensin-(1-7) promotes therapeutic actions in a model of eosinophilic and meutrophilic asthma.(2021) Magalhães, Giselle Santos; Gregório, Juliana Fabiana; Ribeiro, Arthur Tonani Pereira Cançado; Baroni, Isis Felippe; Vasconcellos, Ana Victoria de Oliveira; Nakashima, Gabriela Pansanato; Oliveira, Isabel Fusaro Aguiar; Matos, Natália Alves de; Castro, Thalles de Freitas; Bezerra, Frank Silva; Sinisterra, Ruben Dario; Pinho, Vanessa; Teixeira, Mauro Martins; Santos, Robson Augusto Souza dos; Machado, Maria da Glória Rodrigues; Santos, Maria José Campagnole dosThe presence of eosinophils and neutrophils in the lungs of asthmatic patients is associated with the severity of the disease and resistance to corticosteroids. Thus, defective resolution of eosinophilic and neutrophilic inflammation is importantly related to exacerbation of asthma. In this study, we investigated a therapeutic action of angiotensin-(1-7) (Ang-(1-7)) in a model of asthma induced by ovalbumin (OVA) and lipopolysaccharide (LPS). Balb-c mice were sensitized and challenged with OVA. Twentythree hours after the last OVA challenge, experimental groups received LPS, and 1 h and 7 h later, mice were treated with oral formulation of Ang-(1-7). On the next day, 45 h after the last challenge with OVA, mice were subjected to a test of motor and exploratory behavior; 3 h later, lung function was evaluated, and bronchoalveolar lavage fluid (BALF) and lungs were collected. Motor and exploratory activities were lower in OVA + LPSchallenged mice. Treatment with Ang-(1-7) improved these behaviors, normalized lung function, and reduced eosinophil, neutrophil, myeloperoxidase (MPO), eosinophilic peroxidase (EPO), and ERK1/2 phosphorylation (p-ERK1/2) in the lungs. In addition, Ang-(1-7) decreased the deposition of mucus and extracellular matrix in the airways. These results extended those of previous studies by demonstrating that oral administration of Ang-(1-7) at the peak of pulmonary inflammation can be valuable for the treatment of neutrophil- and eosinophil-mediated asthma. Therefore, these findings potentially provide a new drug to reverse the natural history of the disease, unlike the current standards of care that manage the disease symptoms at best.Item Positronium formation in lanthanide (III) trifluoroacetate with 3-picoline-N-oxide compounds.(2001) Netto, Antônio Marques; Carvalho, Cornélio de Freitas; Carvalho, Carlos Alberto Alves de; Sinisterra, Ruben Dario; Brito, Hermi Felinto de; Machado, José CaetanoPositron annihilation lifetime and Doppler broadening annihilation radiation line shape on the salts Ln(CF3COO)3•xH2O and the adducts Ln(CF3COO)3(3-picNO)•xH2O (Ln=La–Pr, Sm–Lu and Y, and 3-picNO=3picoline-N-oxide, x in the range 0.75–1.33) were performed. Positroniumformation in the adducts, except for the europium complex, was observed. These results are discussed in terms of the electronic properties of the central metal ions.Item Structural and physical–chemical evaluation of bradykinin potentiating peptide and its high soluble supramolecular complex.(2010) Sousa, Frederico Barros de; Denadai, Ângelo Márcio Leite; Lula, Ivana Silva; Ianzer, Danielle Alves; Malaspina, Érica Resende; Camargo, Antônio Carlos Martins de; Santos, Robson Augusto Souza dos; Sinisterra, Ruben DarioThe supramolecular interactions between a Bradykinin Potentiating Peptide (BPP10c) and b-cyclodextrin (bCD) have been investigated by using several techniques. These new properties acquired by the inclusion phenomena are important in developing a strategy for pharmaceutical formulation. The BPP10c structural elucidation and its inclusion complex formed have been investigated using Nuclear Magnetic Resonance techniques. The peptide secondary structure was investigated using infrared spectroscopy in solution, Circular Dichroism and NMR. In addition, the thermodynamic parameters of the inclusion process were also evaluated using Isothermal Titration Calorimetry. The results obtained by these physical– chemical techniques suggested a 1:1 complex formed by interaction between the Tryptophan amino acid residue and the bCD cavity. The peptide secondary structure was not substantially modified for the inclusion process. In addition, the inclusion process proved to be spontaneous (DG8 = -2.53 kcal mol-1), with an enthalpy reduction (DH8 = -3.72 kcal mol-1) and a favored entropic variation (TDS8 = -1.19 kcal mol-1).Item Studies of the interaction of the salicylideneserinatecopper(II) complex with β-cyclodextrin : characterization and reactivity of the inclusion compound.(1999) Sinisterra, Ruben Dario; Mielli, Renata Vicentini; Carvalho, Carlos Alberto Alves de; Silva, Wendel Gomes da; Mangrich, Antonio Salvio; Ferreira, Ana Maria da CostaThe compound formed by the copper-Schiff base complex salicylideneserinatecopper(II), [Cu(sal-ser)(H2O)], interacting with β-cyclodextrin was prepared, and characterized in the solid state by infrared, UV-visible and EPR spectroscopies, X-ray diffraction, and thermoanalytical techniques. The catalytic activity of this compound, [Cu(sal-ser)CD], in the decomposition of hydrogen peroxide, and in the dismutation of superoxide radicals was also verified, in comparison with the reactivity of the free complex, in aqueous solution. In both cases, a decreasing in the reaction rate was observed for the CD-containing compound. The results of structural characterization, in addition to the substantial differences observed in the catalytic activities of the compounds, are indicative of partial insertion of the copper complex in the cavity of the oligosaccharide.Item Thermal behaviour and isothermal kinetics of rhodium(II) acetate.(1997) Carvalho, Cornélio de Freitas; Braga, Mauro Mendes; Yoshida, Maria Irene; Sinisterra, Ruben DarioThe thermal decomposition of solid rhodium(II) acetate was studied by isothermal TG. Kinetic analysis of the isothermal data showed that the complex decomposition in the range 198.0-210.5°C occurs according to a Prout-Tompkins (An) law. The isothermal curves are better fitted using a non-linear least square method. The activation energy found was 16:2.7 kJ tool ~. At temperatures higher than 210.5°C the decomposition is strongly accelerated and no kinetic study was available.